北京社区妇女生殖道人乳头瘤病毒感染及子宫颈上皮内瘤变流行病学调查

赵超; 李静; 屠铮; 宋丹; 崔淑慧; 章文华; 乔友林; 王建六; JeromeBelinson; 魏丽惠

Abstract

赵超,李静,屠铮,宋丹,崔淑慧,章文华,乔友林,王建六,JeromeBelinson,魏丽惠.北京社区妇女生殖道人乳头瘤病毒感染及子宫颈上皮内瘤变流行病学调查[J].Chinese journal of Epidemiology,2007,28(10):947-950

北京社区妇女生殖道人乳头瘤病毒感染及子宫颈上皮内瘤变流行病学调查

Study on the correlation between human papillomavirus infection and cervical among women living in community of Beijing

Received:July 05, 2007

DOI：

KeyWord: 人乳头瘤病毒宫颈病变筛查宫颈细胞学

English Key Word: Human papillomavirus Cervical lesion screening Cervical cytology

FundProject:癌症基金会与Cleveland Clinic Foundation,USA合作基金资助项目和北京大学"985工程"二期资金资助项目(985-2-015-24);北京地区宫颈病变现状调查及防治对策研究课题资助项目(D090608040391)

Author Name	Affiliation	E-mail
Zhao Chao	Department of Gynecology, Peking University People's Hospital, Beijing 100044, China
Li Jing	中国医学科学院肿瘤研究所
Tu Zheng	Department of Gynecology, Peking University People's Hospital, Beijing 100044, China
Song Dan	中国医学科学院肿瘤研究所
Cui Shuhui	Department of Gynecology, Peking University People's Hospital, Beijing 100044, China
Zhang Wenhua	中国医学科学院肿瘤研究所
Qiao Youlin	中国医学科学院肿瘤研究所
Wang Jianliu	中国医学科学院肿瘤研究所
Jerome Belinson	Cleveland Clinic Foundation. USA(Jerome Belinson)
Wei Lihui	Department of Gynecology, Peking University People's Hospital, Beijing 100044, China	weilh@bjmu.edu.cn

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Abstract:

目的探讨北京市社区妇女中高危型人乳头瘤病毒(HPV)感染及子宫颈上皮内瘤变(CIN)状况。方法 2006年6月至2007年6月对北京市展览路社区的795名20~54岁有性生活妇女进行筛查。筛查对象接受妇科检查时，依次留取超柏氏薄层液基细胞学(LCT)和高危型HPV(hc2)检测标本，并对宫颈细胞学异常者行阴道镜检查及活检。结果 795名社区妇女中高危型HPV感染阳性112例，占14.1 %；阴性683例，占85.9 %。高危型HPV感染率随宫颈病变加重，阳性率升高:正常宫颈及慢性宫颈炎人群为0.8%(6/751);CIN1为83.3% (10/12),CIN2及以上为100% (8/8);宫颈细胞学阳性并行阴道镜活检的4。例中，发现11例慢性宫颈炎、14例宫颈湿疣,5例CIN1、3例CIN2、4例CIN3及1例早期浸润癌;细胞学阴性的750人中，发现2例宫颈湿疣,5例CIN1及1例宫颈低级别腺上皮内病变(CGIN)。750人中HPV阴性为669人，其中发现3例CIN1及1例CGIN；HPV阳性为81例，其中2例CIN1及2例官颈湿。在细胞学阳性≥ASCUS)的40例中,HPV阴性为13例，其中发现10例慢性宫颈炎及3例宫颈沉斑；HPV阳性为27例，发现1例慢性宫颈炎、11例宫顶湿疵,7例CIN1、3例CIN2 、4例CIN3及1例早期浸润癌，对官颈病变的检出率后两者相比差异有统计学意义(P<0.001)。结论北京市社区妇女中高危型HFV感染率随子宫颈上皮内瘤变加重，阳性率升高。

English Abstract:

Objective To observe the correlation between human papillomavitus(HPV) infection and cervical lesion among women living in community of Beijing.Methods A total of 795 women at age 20-54,living in Zhanlanlu District of Beijing were screened for cervical lesion.Samples of cervical cytology (LCT) and HPV test (hc2) were collected.Colposcopy arid biopsy were conducted in women with positive LCT.Results In those 795 women,the infection rate of HPV was 14.1%(112/795).In 40 women who were LCT positive 1 early invasive cervical cancer,4 cervical intro-epithelial neoplasia(CIN3),3 CIN2 and 7 CIN1 were noticed.In 750 women with negative LCT,5 CIN1 and 1 low-grade CGIN were diagnosed.In those women who were Cytn(+)and HPV(+),15 cases (55.6%,15/27) were diagnosed with≥CIN1 (including 7 C1N1,3 CIN2,4 CIN3 and 1 early invasive cancer).Conclusion The risk of cervical lesion significantly inctrased in women sfwwing positive in cytology and HPV test.

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