| 郭志荣,胡晓抒,陈冯梅,武鸣.C反应蛋白水平与传统冠心病危险因素分析[J].Chinese journal of Epidemiology,2007,28(11):1064-1068 |
| C反应蛋白水平与传统冠心病危险因素分析 |
| Study On C-reactive protein and the risk factors of traditional coronary heart disease |
| Received:March 12, 2007 |
| DOI： |
| KeyWord: 冠心病 c反应蛋白 危险因素 |
| English Key Word: Coronary heart disease C-reactive protein Risk factors |
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| Abstract: |
| 目的了解江苏省人群c反应蛋白(cRP)的水平与传统冠心病(cHD)危险因素的关系。方法通过“江苏省多代谢异常和代谢综合征综合防治研究”资料，比较高敏c反应蛋白(hs-CRP)(hS-CRP：l，～2.99 mg／L和≥3 mg／L)与传统CHD危险因素：体重指数(BMI)、吸烟、高血压、高血糖、高胆固醇、高三酰甘油、低高密度脂蛋白胆固醇、体力活动缺乏等的关系。结果高hs-CRP罹患率均随血压、血糖、胆固醇、三酰甘油、BMI、吸烟、体力活动(无、轻、中、重)增加而增高，但当hs.CRP(1～2.99 mg／L)时，传统CHD危险因素中大部分未表现出显著联系；随着Framingham心脏积分(5个危险因素)合并数量增加，高hs-cRP呈明显的等级性变化趋势；logistic回归分析表明，hs-CRP(≥3 mg／L)时，BMI、三酰甘油、高血压、高密度脂蛋白胆固醇、吸烟、血糖的0R值均有统计学意义，但hs-cRP(1～2.99 mg／L)时，传统cHD危险因素的oR估计值大部分无统计学意义；男性中60.98％和女性中59.02％的高CRP可以归因于传统cHD危险因素。结论传统cHD危险因素与hs-CRP水平关系密切，目前在临床上、人群研究中根据CRP水平的高低判断CHD风险的实际意义值得进一步探讨。 |
| English Abstract: |
| objective To ascertain the relationship between C-reactive protein(hs-cRP)and“skfactors of traditional cor。nary heart disease(CHD)in a sampled population from Jiangsu province of China.methods Using data derived from a proiect on multiple metabolic disorders and metab01ic syndrome inJiangsu province，a cross-sectional study was car“ed out.Criteria was set as：CRP level categories from 1 to2.99 mg／L，and greater than 3 mg／L，t。explore the relationship between different category of cRP andrisk factors of traditional coronary heart disease which would include body mass index(BⅣII)， cigarettesmoking，high bl∞d pressure， bl∞d glucose， total c}101esterDl level， triglyceride (TG)， high-densitylipoprotein cholesterol(HDL-C) level， physical activity etc. results The attack rate of high CRPincreased with the degree of risk factors related to traditional coronary heart disease. However， whenhs-CRP fell between 1-2.99 mg／L， part of the traditional risk factors would display significance.Significance increased in high CRP related to grading was observed across the Framingham heart score(quintiles).Data frOm the logistic regression analysis sh。wed that：when hs*cRP(≥3 mdL)，theoR ofBMI， TG， high bl∞d pressure， HDL-C， cigarette smoking， blo。d glucose all appeared statisticalsignificance whereas hs。CRP between 1-2.99 mg／L，the O尺of trationaI CHD“sk factors did not showstatistical significance but 60.98％ of the males and 59.02％ of the females would have high hs-CRPincriminate traditional CHD risk factors.ConcIusion As the close relationshiD between traditional CHDrisk factors and hs.CRP was seen，the role of hs-CRP in estimating the risk of CHD was limited，despitethe origin of data，either from clinical or from cohort study. |
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