| 王波,詹思延,夏愔愔,李立明.乙二胺四乙酸铁钠改善铁缺乏人群血红蛋白水平的系统综述[J].Chinese journal of Epidemiology,2008,29(1):65-70 |
| 乙二胺四乙酸铁钠改善铁缺乏人群血红蛋白水平的系统综述 |
| Effect of NaFeEDTA on hemoglobin level in iron deficient population: a systematic review |
| Received:September 20, 2007 Revised:June 08, 2012 |
| DOI： |
| KeyWord: 贫血 乙二胺四乙酸铁钠 铁缺乏 |
| English Key Word: Severe acute respiratory syndrome Immuno-fluorescence assay Antibody |
| FundProject:国家重点发展计划“863”计划资助项目(2003AA208406) |
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| Abstract: |
| 目的 评价乙二胺四乙酸铁钠(NaFeEDTA)改善铁缺乏人群血红蛋白水平的效果.方法 通过检索电子数据库、手工检索相关期刊书籍、收集灰色文献、查找会议摘要、联系相关领域专家，并通过查找参考文献进行全面的文献检索|使用Cochrane EPOC制定的标准对纳入研究的质量进行了评价|使用广义倒方差法对各结局的纳入研究进行Meta分析.结果在铁缺乏人群，NaFeEDTA使血红蛋白浓度增加12.14 g/L(加权均差|95%C/:5.60～18.69|P＜0.001).亚组分析提示更低的基线血红蛋白浓度、更高的干预剂量可能导致更大的血红蛋白浓度增加.结论NaFeEDTA可以有效改善铁缺乏人群的血红蛋白浓度。 |
| English Abstract: |
| Objective To explore the temporal profile of serum antibody against coronavirus in patients with severe acute respiratory syndrome (SARS), and to evaluate the reliability of indirect immuno-fluorescence assay (IFA) in the diagnosis of SARS.Methods Clinically confirmed SARS patients, suspected SARS patients, and controls were included in the study. IFA was used to detect the serum antibody against SARS coronavirus. General information about the subjects was collected using a standard questionnaire.Results The positive rates of specific IgG and IgM against SARS virus within 10 days after onset of the disease were 55.1% and 16.3% respectively and then increased up to 89.8% for IgG and 65.3% for IgM. After 25 days of the onset of the disease, 90.9% patients became positive for both IgG and IgM.Results from chi-square for trend test revealed that the positive rates of both IgG and IgM increased with time (χ2 for trend=16.376, P=0.000 05 for IgG; χ2 for trend=28.736, P=0.000 00 for IgM). Sensitivity, specificity and agreement value of IFA regarding the diagnosis of SARS were all higher than 90%. Conclusions IFA can be used to assist diagnosis of SARS after 10 days of the onset of desease. |
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