安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响

吴静; 胡东; 朱钰; 张荣波

Abstract

吴静,胡东,朱钰,张荣波.安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响[J].Chinese journal of Epidemiology,2008,29(3):245-247

安徽地区儿童暴露于农村生活环境对过敏性哮喘的影响

The effect of rural exposure on allergic asthma in Anhui province

Received:August 17, 2007 Revised:August 17, 2007

DOI：

KeyWord: 哮喘过敏暴露儿童

English Key Word: Asthma Allergy Exposure Children

FundProject:

Author Name	Affiliation	E-mail
WU Jing	Medical College, Anhui University of Science&Technology, Huainan 232007, China
HU Dong	Medical College, Anhui University of Science&Technology, Huainan 232007, China
ZHU Yu	淮南新华医疗集团新华医院检验中心
ZHANG Rong-bo	Medical College, Anhui University of Science&Technology, Huainan 232007, China	lory41@126.com

Hits: 2623

Download times: 866

Abstract:

目的研究暴露于农村生活环境对预防儿童哮喘及致敏的保护作用.方法向2986名在校儿童父母发放哮喘标准调查表,采用放射性变应原荧光酶免疫吸附实验(RAST-FEIA)检测儿童血清中特异性IgE(sIgE)含量.结果与在城镇生活的儿童相比,暴露于农村生活环境儿童的过敏性哮喘与非过敏性哮喘、过敏性哮鸣及特应性哮呜危险度显著性降低(OR=0.45,95%CI:0.13～0.96:OR=0.41,95%CI:0.15～0.95;OR=0.32,95% CI:0.11～0.62;OR=0.44,95% CI:0.13～0.91).1周岁内暴露与农村生活环境的儿童过敏性哮喘及特应性致敏危险度较低(OR=0.23,95% CI:0.04～0.91;OR=0.32,95%CI:0.17～0.78);若暴露持续至6周岁,过敏性哮喘及特应性致敏危险度更低(OR=0.21,95%CI:0.03～0.87;OR=0.31,95%CI:0.15～0.78).结论 暴露于农村环境对预防儿童过敏性哮喘及致敏的发生可能有保护作用,持续的暴露能加强此作用.

English Abstract:

Objective To establish the evidence of exposure to rural areas would reduce the risk of atopic asthma and sensitization. Methods A cross-sectional survey was carried out in 2986 school-age children and their parents completed standardized questionnaires on atopic asthma and sensitization, wheezing. A radioallergosorbent technique-fluorescence enzyme immunoassay (RAST-FEIA) was used to measure the level of specific IgE in serum. Results The risks of atopic and non-atopic asthma(OR= 0.45,95 % C1:0.13-0.96 and OR二0. 41, 95 % CI : 0. 1 S-0. 95 ), atopic sensitization and wheezing(OR= 0.32,95 % CI:o. tl-a.6z;OR=0.44,95 % C1:0.13一0.91)were lower in subjects living in village area compared with those living in towns. The risks of atopic asthma and sensitization were lower in subjects exposed to stables in first year(OR=0.23,95 % CI:0.04-0.91 and OR=0.32,9596 C1:0.77-0.78) and were lowest in those exposed continually until the age of 6(OR=0.21，95 0.6 CI : 0. 03-0. 87 and OR= 0. 31, 95 % CI :0. 1 S-0. 78 ) compared with those non-exposed in the first 6 years. Conclusion Exposure to rural environment might have a protective effect on children against atopic asthma and sensitization while continual exposure could strengthen the effects.

View Fulltext Html FullText View/Add Comment Download reader