| 刘静,赵冬,王薇,孙佳艺,刘军,王森,秦兰萍,吴兆苏.中国11省市代谢综合征不同组分及其组合 形式与心血管病发病的关系[J].Chinese journal of Epidemiology,2008,29(7):652-655 |
| 中国11省市代谢综合征不同组分及其组合 形式与心血管病发病的关系 |
| Incidence risk of cardiovascular diseases associated with specific combinations regarding the metabolic syndrome components |
| Received:February 22, 2008 |
| DOI： |
| KeyWord: 心血管疾病 代谢综合征 前瞻性队列研究 |
| English Key Word: Cardiovascular diseases Metabolic syndrome Prospective cohort study |
| FundProject:国家“八五”科技攻关课题资助项目(85-915-01-02); 北京市心血管病研究实验室资助项目(953850700) |
| Author Name | Affiliation | | LIU Jing | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | ZHAO Dong | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | WANG Wei | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | SUN Jia-yi | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | LIU Jun | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | WANG Miao | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | QIN Lan-ping | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China | | WU Zhao-su | Department of Epidemiology, Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Beijing 100029, China |
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| Abstract: |
| 目的 研究代谢综合征(MS)不同组分及其组合形式与心血管病(CVD)发病危险的关系。方法 “中国多省市心血管病前瞻性队列研究”在11省市共人选35~64岁男女两性30 378人,1992-2004年随访期间共发生急性CVD事件809例。采用《中国成人血脂异常防治指南》中定义的 MS新标准分析MS的分布特征和MS各组分不同组合与CVD发病的关系。结果 (1)根据新标准,中国人群MS患病率为11.8%,男女分别为12. 4%和9.0%,男性高于女性(P<0.001)。(2)调整其他 危险因素后,CVD危险随MS组分个数的增加而增加。仅有1个组分时,只有血压升高显著增加 CVD危险;有2个组分时,10种组合中的5种显著增加CVD危险;>3个组分(即MS)存在时共有16 种组合,除4种罕见组合外,其他12种均显著增加CVD危险,其中危险最高的前7位均具有“腹部肥 胖+血压升高”的特征。结论 MS各组分的不同组合形式所具有的CVD发病危险有很大差异,>3 组分,特别是包含腹部肥胖和血压升髙者,可以较好地检出CVD危险较高的个体。 |
| English Abstract: |
| Objective To investigate the risk of cardiovascular diseases (CVD) incidence related to different combinations of the metabolic syndrome(MS) components. Methods A total of 30 378 subjects aged 35 to 64 years were recruited from 11 provinces in a Chinese Multi-provincial Cohort Study and followed-up for new CVD from 1992 to 2004.MS was defined under the new criteria ‘Preventiveguideline of Dyslipidemia for Chinese Adults ’, issued in 2007 ? CVD incidence rates and relative risks (RR) were estimated by different MS components and by their various combinations. Results (1) According to the new criteria,the prevalence of MS was 11.8%for Chinese middle-age adults. The prevalence was 12.4%in men，significantly higher than that in women (9.0%). (2) Risk of CVD increased in proportion to the number of MS components after adjusting for other risk factors. If only 1 component was present, elevated blood pressure was the only significant predictor of CVD. When 2 components were present, 5 of the 10 combinations were associated with significantly higher risk. All combinations with ^3 components(MS) had significant contribution except for those rare traits (<0.5%of the whole sample). Among the 16 combinations of ^3 components, the feature of “central obesity and elevated blood pressure” was found in all the 7 combinations with the highest risk. Conclusion CVD risk associated with various number and combinations of MS components seemed to be heterogeneous. The clustering of ^3 disorders, especially those with central obesity and elevated blood pressure could significantly predict the future development of CVD. |
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