无锡市城区20岁以上人群乙型肝炎病毒感染及免疫状况调查

钱燕华; 林玉娣; 沈洪兵; 董美华; 邓于; 缪小兰; 王旭雯; 顾静; 陈峰; 喻荣彬

Abstract

钱燕华,林玉娣,沈洪兵,董美华,邓于,缪小兰,王旭雯,顾静,陈峰,喻荣彬.无锡市城区20岁以上人群乙型肝炎病毒感染及免疫状况调查[J].Chinese journal of Epidemiology,2008,29(8):783-786

无锡市城区20岁以上人群乙型肝炎病毒感染及免疫状况调查

tudy on the prevalence rate and immunity of hepatitis B virus infection among urban adults aged over 20 years in Wuxi, Jiangsu province

Received:December 18, 2007 Revised:June 18, 2012

DOI：

KeyWord: 乙型肝炎病毒自然人群免疫状况

English Key Word: Hepatitis B virus Natural population Immunity

FundProject:江苏省现代病原生物学重点实验室开放基金资助项目(1623)；江苏省预防医学科研基金资助项目(Y2006003)；2006年度无锡市社会发展科技指导性计划资助项目(CLZ00632)

Author Name	Affiliation	E-mail
qian yan-hua	江苏省无锡市疾病预防控制中心,214023	kanbiao@icdc.cn
lin yu-di	江苏省无锡市疾病预防控制中心,214023
shen hong-bind	南京医科大学流行病与卫生统计学系,214023
dong mei-hua	江苏省无锡市疾病预防控制中心,214023
deng yu	江苏省无锡市疾病预防控制中心,214023
liao xiaolan	江苏省无锡市疾病预防控制中心,214023
wang xun-wen	江苏省无锡市疾病预防控制中心,214023
gu jing	江苏省无锡市疾病预防控制中心,214023
chen feng	南京医科大学流行病与卫生统计学系,214023
yu rong bing	南京医科大学流行病与卫生统计学系,214023

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Abstract:

目的<\b>对江苏省无锡市城区20岁以上自然人群I-IBV感染与乙型肝炎(乙肝)疫苗接种关系进行研究。方法<\b>按知情、自愿、随机的原则抽取无锡市20岁以上的自然人群3744名进行乙肝血清流行率和乙肝疫苗接种调查，采用ELISA和放射免疫分析法测定乙肝五项指标(HBsAg、抗一HBs、I-IBeA唱、抗一HBe和抗．HBc)。结果<\b> 3744名调查对象总HBV感染率经标化后为51．7％，HBsA喀、抗一HBs、HBeAg、抗．me、抗一耶c阳性率经标化后分别为4．5％、48．5％、0．3％、3．5％、51．4％。30岁以下人群HBsAg阳性率最低，分别为2．9％和2．6％。抗一HBc阳性率男性显著高于女性(P<0．05)，且随着年龄的增加而逐步升高(趋势12=256．2，P<0．001)。该人群乙肝疫苗标化接种率为17．6％，随着年龄的增加接种率迅速下降(P<0．05)。接种疫苗人群的I-IBSAg阳性率和I-IBV感染率明显低于未接种疫苗人群、抗一FIBs阳性率则高于未接种人群(P值均<0．05)。结论<\b>成年人接种乙肝疫苗可以影响整个人群的HBV感染模式，在加强新生儿乙肝疫苗计划免疫同时，应进一步加强对成年人的乙肝疫苗免疫策略。

English Abstract:

Objective To study the relationship on the prevalence rate of hepatitis B virus (HBV) infection and hepatitis B vaccination in urban citizens aged over 20 years old which would led to the development of strategies on HBV control. Methods A total of 3744 subjects from general population were randomly selected in this study. Both ELISA and radio immunoassay were used to test five items of HBV infection, including HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc. Results The overall standardized infection rate of HBV was 51.7%, and HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 4.5%,48.5 %, 0.3 %, 3.5 % and 51.4 %, respectively. The two lowest HBsAg positive rates were found in the groups under 30 years old (2.9%) and students (2.6%). Anti-HBc rate among men was significantly higher than seen in women (P<0.05), and showing a trend of increase with age (χ2> for trend= 256.2,P<0.001 ). The standardized rates of HB vaccination in this population was 17.6% and decreasing rapidly with age (P<0.05). People who had been vaccinated had both lower rates of HBsAg and HBV infection but higher rate of anti-HBs than those who had not (P<0.05). Conclusion liB vaccination in adults showed a reducing rate of HBV infection in the general population. Together with the enhancement of expanded program on immunization to wards HB vaccination in neonates, much attention should be paid to HB vaccination in adults.

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