| 陈曦,邢辉,贺健梅,郑军,邹潇白,阮玉华,卓碧云,邵一呜.湖南省HIV一1耐药警戒线调查[J].Chinese journal of Epidemiology,2008,29(8):787-789 |
| 湖南省HIV一1耐药警戒线调查 |
| Study on the threshold of HIV-1 drug resistance in Hunan province |
| Received:April 14, 2008 Revised:June 20, 2012 |
| DOI： |
| KeyWord: 艾滋病病毒 耐药监测 抗病毒治疗 艾滋病病毒警戒线调查 |
| English Key Word: Human immunodeficieney virus-1 Drug resistance surveillance Antiretroviral treatment：HIV drug resistance threshold survey |
| FundProject:世界卫生组织．瑞典国际开发合作署资助项目(wP/2006/(：HN/HIv/1．2/002/03．03．AW．01)；国家高科技“863”课题资助项目(2006AA027．418) |
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| Abstract: |
| 目的<\b> 了解湖南省开展艾滋病抗病毒治疗以来，年龄<25岁新近感染HIV一1且未服抗病毒药者出现耐药毒株的变异情况。方法<\b> 通过横断面调查，采集15～24岁HIV一1感染者的血清样本．进行HIV一1 pol区耐药基因变异检测分析。结果<\b>69份有效样本中，在RT区1份样本出现可以导致针对NNRTIs系列的NVP、DLV和EFV药物的高度耐药性的K103N、V181C的2个主要耐药突变，1份样本出现可以导致对D4T的低度耐药性和对DDI的潜在耐药性的V75M耐药突变。PR区没有检测到高度耐药突变株。在RT区高度耐药株检出率为2．9％(2/69)，说明湖南省HIV耐药株的传播仍处于低度范围内(<5％)。结论<\b>表明现有的一线治疗方案是有效的，个体病例尚不需要在治疗开始前进行耐药性检测。但也提示应该加强对早期感染者的耐药监测工作。 |
| English Abstract: |
| 0bjective To survey the prevalence of HIV一1 drug resistance in patients newly diagnosed as HIV positive and Who were younger than 25 years of age but had not received treatment with antiretroviral treatment(ART)in Hunan province．Methods Serum specimens of HIV infected individuals were collected and HIV．1 pol genetic mutations a鞭sociated with drug resistance were identified with PCR and interpreted with Stanford HIV Drug Resistance Database．Resuits A total number of 69 patients whose HIV sequences were amplified successfully with 2(2．9％)specimens appeared mutations associated with HIv-l drug resistance in the reverse transcriptase region．including one a8 v75M and the other one as K103N and V181C．Data showed that the prevalence of drug resistance in Huna．n was 2．9％．Conclusion The first line regiments of nationaI ART seemed stilI effective．Most of the AIDS patients did not need tO be tested on drug resistance status before starting ART．However．it is important to start HIV drug resistance surveillanee in no time． |
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