| 任艳军,李秀央,陈坤,刘庆敏,项海青,金达丰,陈仁华.大气颗粒物污染与脑卒中死亡的病例交叉研究[J].Chinese journal of Epidemiology,2008,29(9):878-881 |
| 大气颗粒物污染与脑卒中死亡的病例交叉研究 |
| A case-crossover study on air pollutants and the mortality of stroke |
| Received:May 13, 2008 |
| DOI： |
| KeyWord: 脑卒中|颗粒物|大气污染|病例交叉研究|时间分层 |
| English Key Word: Stroke|Particulate matter|Air pollution|Case-crossover study|Time-stratification |
| FundProject: |
| Author Name | Affiliation | E-mail | | REN Yan-jun | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China | | | LI Xiu-yang | Deportment of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310058, China | | | CHEN Kun | Deportment of Epidemiology and Health Statistics, School of Medicine, Zhejiang University, Hangzhou 310058, China | ck@ziu.edu.cn | | LIU Qing-min | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China | | | XIANG Hai-qing | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China | | | JIN Da-feng | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China | | | CHEN Ren-hua | Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China | |
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| Abstract: |
| 目的 评价大气颗粒物污染对人群脑卒中死亡的急性效应.方法 采用时间分层的病例交叉设计,分析杭州市2002-2004年间大气可吸入颗粒物(PM10)日平均浓度短期增加与人群每日脑卒中死亡的关系,同时分析其他气态污染物(NO2和SO2)的急性健康效应。结果共纳入9906例脑卒中死亡病例,粗死亡率约为83.54/10万。调整气象因素后,3d内PM10、SO2和NO2日平均浓度每增加10μg/m3,人群脑卒中死亡则分别增加0.56%(95%CI:0.14%～0.99%)、1.62%(95%CI:0.26%～3.01%)和2.07%(95%CI:0.54%～3.62%)。多污染物模型中未见有统计学意义的关联.敏感性分析结果显示进行缺失值填补后,单污染物模型中均有关联效应,多污染物模型中则无统计学意义的关联。结论大气颗粒物污染以及SO2和NO2污染物浓度短期升高均与脑卒中死亡增加存在一定关联。 |
| English Abstract: |
| Objective To investigate the short-term effect of particulate matter in air on the mortality of stroke. Methods Using time-stratified case-crossover study design,an association was examined between stroke mortality and particulate matter with aerodynamic diameter of ＜10μm(PM10) of 2002- 2004 in Hangzhou city.Meanwhile,the acute health effect of other gaseous pollutants (sulfur dioxide,SO2 and nitrogen dioxide,NO2) was also analyzed.Results A total of 9906 deaths of stroke were included.The crude stroke mortality was 83.54 per 100 000.After being adjusted for meteorological factors,when an increase of 10 μg/m3 in PM10,SO2 and NO2 in three days was noticed,it appeared that the increases of mortality of stroke were 0.56%(95%CI:0.14%-0.99%),1.62%(95%CI:0.26%-3.01%) and 2.07%( 95%CI:0.54%-3.62%) respectively.There was no distinct association in multipollutant models.In sensitivity analysis,the associations were found in all single-pollutant models but not statistically significant in multi-pollutant models after replacing the missing values.Conclusion It is suggested that the short-term elevation in PM10 as well as SO2 and NO2 daily concentrations were related to the increase of stroke mortality in Hangzhou city. |
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