| 冯向先,段培芬,王丽冰,张建斌,卢祖洵.XPA基因多态性与食管癌易感性关系的研究[J].Chinese journal of Epidemiology,2008,29(9):930-933 |
| XPA基因多态性与食管癌易感性关系的研究 |
| Study on the relationship between polymorphisms of XPA gene and susceptibility of esophageal cancer |
| Received:May 06, 2008 |
| DOI： |
| KeyWord: 食管癌|基因多态性 |
| English Key Word: Esophageal cancer|Genetic polymorphisms |
| FundProject:山西省回国留学人员科研基金资助项目(200565) |
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| Abstract: |
| 目的 探讨长治地区食管癌高发的主要环境危险因素和参与DNA损伤修复的XPA基因多态性与食管癌易感性的关系,以及与环境因素之间对食管癌发生的交互作用。方法 采用病例对照研究,对196例食管癌患者和201例对照者进行食管癌相关因素的问卷调查,应用PCR-RFLP技术对XPA 23G多态性基因型检测,采用SPSS 12.0统计软件对研究结果进行分析。结果病例组携带突变(G)等位基因的频率明显低于对照组(X2=18.31,P＜0.01);XPA基因三种基因型在两组间差异有统计学意义(X2=16.56,P＜0.01),且携带有xPA突变杂合子(A/G)和突变纯合子(G/G)的个体发生食管癌的危险性比携带野生纯合子(A/A)个体低[OR值(95%CI)分别为0.58(0.37～0.91)和0.32(0.18～0.56)]。携带XPA突变基因G与经常食用腌制食品之间存在负交互作用(S=0.04,API=-0.77)。结论XPA 23G多态性可能与长治地区食管癌的发生有一定关系,携带XPA突变基因G可抑制食用腌制食品对食管癌的发生。 |
| English Abstract: |
| Objective To explore the relationships between the polyrnorphisms of xeroderma pigmentosum A(XPA) and the susceptibility of esophageal cancer (EC),as well as its interaction with environmental factors-gene in Changzhi area,Shanxi province.Methods A case-control study was conducted,including 196 cases of EC and 201 controls.XPA 23G polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).Results The risk of EC was significantly degraded in the individuals who had been carrying the XPA heterozygote (A/G) and mutation genotype (G/G),compared to those with wild genotype (X2=16.21,P＜0.01) and the ORs were 0.58 (0.37-0.91) and 0.32 (0.18-0.56),respectively.There was negative interaction between XPA 23G mutation genotype and the consumption of pickled food (S=0.04,API=-0.77).Conclusion Genetic polymorphism in the XPA 23G might be associated with esophageal cancer in Changzhi area,and there was a negative action between XPA predisposing genotype and the consumption of pielded food. |
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