中国人群先天性心脏病危险因素的Meta分析

余章斌; 韩树萍; 郭锡熔

Abstract

余章斌,韩树萍,郭锡熔.中国人群先天性心脏病危险因素的Meta分析[J].Chinese journal of Epidemiology,2008,29(11):1137-1140

中国人群先天性心脏病危险因素的Meta分析

A Meta-analysis on the risk factors of perinatal congenital heart disease in Chinese people

Received:June 29, 2008

DOI：

KeyWord: 先天性心脏病 Meta分析危险因素比值比

English Key Word: Congenital heart disease Meta-analysis Risk factor Odds ratio

FundProject:

Author Name	Affiliation
YU Zhang-bin	Department of Pediatrics, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China
HAN Shu-ping	Department of Pediatrics, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China
GUO Xi-rong	Department of Pediatrics, Nanjing Maternal and Child Health Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China

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Abstract:

目的探讨中国人群先天性心脏病发生的主要危险因素,为该病防治提供依据.方法利用Meta分析方法分析国内12篇(累计病例3436例,对照3976例)关于先天性心脏病发病危险因素的研究文献.根据齐性检验结果采用计算各危险因素合并OR值及其95%CI.结果单因素合并OR值分别为:母孕期受精神刺激(4.55)、母孕早期有感冒病史(3.18)、孕前接触有毒化合物(3.19)、孕期接触农药(4.85)、孕期有负性生活事件(5.39);多因素合并OR值分别为:母孕期受精神刺激(4.08)、孕期接触有毒化合物(3.54)、母孕期感冒发热(5.00).结论目前影响中国人群先天性心脏病发生的主要因素为母孕期受精神刺激、母孕早期有感冒病史或发热、孕前或孕期接触有毒化合物、孕期接触农药和孕期有负性生活事件.

English Abstract:

Objective To investigate the main risk factors related to the incidence of perinatal congenital heart disease (CHD) in Chinese people. Methods Results on the risk factors of CHD in 12 papers were analyzed by Meta-analysis method. The cumulative cases and controls were 3436 and 3976, respectively. The calculation methods of the combined odds ratio( OR ) and 95 % confidence interval (CI) were determined according to the homogeneity test. Results The pooled OR values of single-factor-analysis were as follows: spiritual stimulus ( 4.55 ), maternal exposures to pesticides ( 4.85 ), negative life events (5.39) during pregnancy, cold (3.18) during early pregnancy, exposure to chemical toxic substances before pregnancy. The pooled OR values of multiple-factor analysis were as follows: spiritual stimulus (4.08), exposure to chemical toxic substances ( 3.54 ), cold with fever ( 5.00 ) during pregnancy. Conclusion The main factors influencing the incidence of CHD in Chinese people were current spiritual stimulus, exposure to chemical toxic substances or pesticides, negative life events during pregnancy, cold or fever during early pregnancy, exposure to chemical toxic substances before pregnancy.

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