广西壮族人群肝癌家族聚集与细胞色素基因多态性等因素关系的研究

盛鹰; 黄天壬; 张振权; 邓伟; 余家华; 张春燕; 周德南; 利基林; 叶司原; 梁任祥; 韦忠亮

Abstract

盛鹰,黄天壬,张振权,邓伟,余家华,张春燕,周德南,利基林,叶司原,梁任祥,韦忠亮.广西壮族人群肝癌家族聚集与细胞色素基因多态性等因素关系的研究[J].Chinese journal of Epidemiology,2009,30(2):151-155

广西壮族人群肝癌家族聚集与细胞色素基因多态性等因素关系的研究

Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome gene in Zhuang populationl Guangxi

Received:July 28, 2008

DOI：

KeyWord: 肝肿瘤家族聚集性细胞色素P450 基因多态性

English Key Word: Hepatocellular carcinoma Familial clustering Cytochrome P450 Genaic polymorphism

FundProject:广西自然科学基金资助项目(0135022)

Author Name	Affiliation	E-mail
SHENG Ying	上海市南汇区中心医院 201300
HUANG Tian-ren	Guangxi Cancer Institute, Nanning 530021, China	Email:tianrenhuang@yahoo.com.cn
ZHANG Zhen-quan	Guangxi Cancer Institute, Nanning 530021, China
DENG Wei	Guangxi Cancer Institute, Nanning 530021, China
YU Jia-hua	Guangxi Cancer Institute, Nanning 530021, China
ZHANG Chun-yan	Guangxi Cancer Institute, Nanning 530021, China
ZHOU De-nan	Guangxi Cancer Institute, Nanning 530021, China
LI Ji-lin	Guangxi Cancer Institute, Nanning 530021, China
YE Si-yuan	Guangxi Cancer Institute, Nanning 530021, China
LIANG Ren-xiang	扶绥县肿瘤防治研究所
WEI Zhong-liang	扶绥县肿瘤防治研究所

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Abstract:

探讨广西壮族人群肝癌高发家族聚集与细胞色素P4502E1(CYP2E1)基因多态性等因素的关系。方法在广西某肝癌高发现场壮族人群中，对10个肝癌高发家族成员(共91名)和10个无癌对照家族成员(共102名)。

English Abstract:

study the relationship between familial clustering of hepatocellular carcinoma(HCC)and the polymorphism of cytochrome gene(CYP2E1)as well as of other relevant risk factors to the cancer.Methods Peripheral blood samples were collected from 91 members of 10 HCC clustering families and 102 of 10 control families,among Zhuang population,in Guangxi.The area had been with high incidence rate of HCC.Genotypes and allele frequencies of CYP2E1 Rsa I site were determined by polymerase chain reaction.combined with restriction fragment length polymorphism method (PCR-RFLP).Serum HBsAg was tested by means of ELISA.Data on relevant risk factors of the cancer were collected as well.through a unique questionnaire.Results Frequencies of c1/c1 and c1/c2 genetypes of CYP2E1 Rsa I site were 63.7%and 36.3%.respectively,in the members of families with cancer clustering phenomena.In the members of the control families.these two rates were 48.0%and 52.0%,respectively (OR=1.901,95%CI:1.067-3.387).Difference of genotypes frequencies of CYP2E1 Rsa I site between the members in these two groups was statistically significant(X2=4.797,P=0.029).According to the results from non-condition logistic regression analysis.the major risk factors on familial clustering of HCC could be listed as:intake of corns.HBsAg carrying status and CYP2E1 c1/c1 genotype.Conclusion The relationship seemed to exist between familial clustering of HCC and the frequencies of polymorphism of cytochrome gene(CYP2E1).The frequencies of CYP2E1 Rsa I site were neither the only nor the major factor,causing the familial clustering phenomenon of cancel More possible,it Was the affect of syntheses with the involvement of multiple factors.

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