| 盛鹰,黄天壬,张振权,邓伟,余家华,张春燕,周德南,利基林,叶司原,梁任祥,韦忠亮.广西壮族人群肝癌家族聚集与细胞色素基因多态性等因素关系的研究[J].Chinese journal of Epidemiology,2009,30(2):151-155 |
| 广西壮族人群肝癌家族聚集与细胞色素基因多态性等因素关系的研究 |
| Study on the relationship between familial clustering of hepatocellular carcinoma and polymorphism of cytochrome gene in Zhuang populationl Guangxi |
| Received:July 28, 2008 |
| DOI： |
| KeyWord: 肝肿瘤 家族聚集性 细胞色素P450 基因多态性 |
| English Key Word: Hepatocellular carcinoma Familial clustering Cytochrome P450 Genaic polymorphism |
| FundProject:广西自然科学基金资助项目(0135022) |
| Author Name | Affiliation | E-mail | | SHENG Ying | 上海市南汇区中心医院 201300 | | | HUANG Tian-ren | Guangxi Cancer Institute, Nanning 530021, China | Email:tianrenhuang@yahoo.com.cn | | ZHANG Zhen-quan | Guangxi Cancer Institute, Nanning 530021, China | | | DENG Wei | Guangxi Cancer Institute, Nanning 530021, China | | | YU Jia-hua | Guangxi Cancer Institute, Nanning 530021, China | | | ZHANG Chun-yan | Guangxi Cancer Institute, Nanning 530021, China | | | ZHOU De-nan | Guangxi Cancer Institute, Nanning 530021, China | | | LI Ji-lin | Guangxi Cancer Institute, Nanning 530021, China | | | YE Si-yuan | Guangxi Cancer Institute, Nanning 530021, China | | | LIANG Ren-xiang | 扶绥县肿瘤防治研究所 | | | WEI Zhong-liang | 扶绥县肿瘤防治研究所 | |
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| Abstract: |
| 探讨广西壮族人群肝癌高发家族聚集与细胞色素P4502E1(CYP2E1)基因多态性等因素的关系。方法在广西某肝癌高发现场壮族人群中，对10个肝癌高发家族成员(共91名)和10个无癌对照家族成员(共102名)。 |
| English Abstract: |
| study the relationship between familial clustering of hepatocellular carcinoma(HCC)and the polymorphism of cytochrome gene(CYP2E1)as well as of other relevant risk factors to the cancer.Methods Peripheral blood samples were collected from 91 members of 10 HCC clustering families and 102 of 10 control families,among Zhuang population,in Guangxi.The area had been with high incidence rate of HCC.Genotypes and allele frequencies of CYP2E1 Rsa I site were determined by polymerase chain reaction.combined with restriction fragment length polymorphism method (PCR-RFLP).Serum HBsAg was tested by means of ELISA.Data on relevant risk factors of the cancer were collected as well.through a unique questionnaire.Results Frequencies of c1/c1 and c1/c2 genetypes of CYP2E1 Rsa I site were 63.7%and 36.3%.respectively,in the members of families with cancer clustering phenomena.In the members of the control families.these two rates were 48.0%and 52.0%,respectively (OR=1.901,95%CI:1.067-3.387).Difference of genotypes frequencies of CYP2E1 Rsa I site between the members in these two groups was statistically significant(X2=4.797,P=0.029).According to the results from non-condition logistic regression analysis.the major risk factors on familial clustering of HCC could be listed as:intake of corns.HBsAg carrying status and CYP2E1 c1/c1 genotype.Conclusion The relationship seemed to exist between familial clustering of HCC and the frequencies of polymorphism of cytochrome gene(CYP2E1).The frequencies of CYP2E1 Rsa I site were neither the only nor the major factor,causing the familial clustering phenomenon of cancel More possible,it Was the affect of syntheses with the involvement of multiple factors. |
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