重庆市中老年钢铁工人颈动脉粥样硬化的流行病学调查

张东平; 李晋芳; 胡长林; 黄辉

Abstract

张东平,李晋芳,胡长林,黄辉.重庆市中老年钢铁工人颈动脉粥样硬化的流行病学调查[J].Chinese journal of Epidemiology,2009,30(4):322-325

重庆市中老年钢铁工人颈动脉粥样硬化的流行病学调查

Prevalence and correlation factors of carotid atherosclerosis among the middle and old aged workers in an Iron and Steel corporation,Chongqing

Received:October 02, 2008

DOI：

KeyWord: 颈动脉粥样硬化现患率钢铁工人流行病学调查

English Key Word: Carotid atherosclerosis Prevalence Iron and steel workers Epidemiological surveys

FundProject:

Author Name	Affiliation
ZHANG Dong-ping	Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
LI Jin-fang	Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
HU Chang-lin	Department of Neurology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
HUANG Hui	重庆钢铁公司总医院神经消化内科

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Abstract:

调查重庆钢铁集团工人颈动脉粥样硬化(CAS)的发生情况及其相关因素。方法从重庆钢铁集团下属烧结厂45～80岁在职及退休职工中随机分层抽样512人，进行标准的问卷调查及血糖、血脂、炎性因子和颈动脉彩超的测定，对与CAS患病可能有关的因素进行多因素logistic回归分析。结果(1)重庆钢铁工人CAS现患率达37.6%，其中颈动脉内膜中层厚度增厚的现患率为10.2%，非狭窄性斑块和狭窄性斑块的现患率分别为25.0%和2.4%。(2)CAS发病的影响因素为年龄(0R=1.289，95%CI：1.014～1.568，P<0.001)、吸烟(0R=1.420，95%CI：0.802～3.872，P<0.001)、高血压(0R=4.530，95%CI：3.952～6.753，P<0.001)、糖尿病(0R=2.285，95%CI：1.008～5.057，P<0.001)、高敏C反应蛋白(0R=1.273，95%CI：0.479-2.889，P=0.037)、高胆固醇血症(0R=1.032，95%CI：0.320～1.882，P=0.047)和高低密度脂蛋白血症(0R=2.313，95%CI：1.237～4.331，P=0.008)。(3)CAS患病率随着其相关因素个数的增加而升高，有1个影响因素的人中CAS患病率增加0.9倍，有2个影响因素的人中CAS患病率增加1.3倍，有3个影响因素的人中CAS患病率增加2.3倍。结论重庆中老年钢铁工人CAS现患率偏高，CAS现患率随着影响因素的聚积而增加。

English Abstract:

investigate the prevalence and correlation factors of carotid atherosclerosis (CAS) among workers of Chongqing Iron and Steel Corporation,and to offer information for the development of prevention program for cerebro-vascular disease.Methods 512 asymptomatic individuals (mean age 56.8 years,ranged from 45 to 80) from the subsidiary workshop of Chongqing Iron and Steel Corporation were recruited.Demographic data and serum were collected and the internal-media thickness (IMT) of the CAS and the extent of plaque formation were evaluated by B-mode ultrasound.Logistic regression analysis was used to estimate the correlation factors of CAS.Results (1) The overall prevalence of carotid atherosclerosis among the iron and steel workers was 37.6%.IMT was found as 10.2%,with the prevalence rates of nonstenotic plaque and stenotic plaque were 25.0% and 2.4% respectively.(2)It was shown by logistic regression analysis that age (0R=1.289,95%CI：1.014-1.568,P<0.001 ),smoking (0R=1.420,95%C1：0.802-3.872,P<0.001 ),hypertension (0R=4.530,95%CI：3.952-6.753,P<0.001),diabetes mellitus (0R=2.285,95%C1：1.008-5.057,P<0.001 ),HsCRP(0R= 1.273,95%C1：0.479-2.889,P=0.037),TC (0R= 1.032,95%C1：0.320-1.882,P=0.047) and LDL-C (0R=2.313,95% CI：1.237-4.331,P=0.008) were significantly associated with the severity of CAS.(3)Prevalence of the CAS increased with the increasing number of correlation factors.Conclusion The prevalence of CAS among the iron and steel workers was higher than those in ordinary people of the same age.Age,smoking,hypertension,diabetes mellitus,HsCRP,TC and LDL-C were independent risk factors related to CAS.The prevalence of CAS was increasing parallel to the number of correlation factors.

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