主动脉弓钙化影响因素的调查与分析

周海林; 江朝强; 林大庆; 郑家强; 刘斌; 张维森; 徐琳; 靳雅丽; 朱彤; ThomasGN

Abstract

周海林,江朝强,林大庆,郑家强,刘斌,张维森,徐琳,靳雅丽,朱彤,ThomasGN.主动脉弓钙化影响因素的调查与分析[J].Chinese journal of Epidemiology,2009,30(8):776-779

主动脉弓钙化影响因素的调查与分析

Impact on calcification of aortic arch by lifestyle-related,physiologic and biochemical factors

Received:December 18, 2008

DOI：

KeyWord: 主动脉弓钙化生活习惯生理生化因素

English Key Word: Aortic arch calcification Lifestyle Physiological and biochemical factors

FundProject:Fogany项目(R01-HL-73699)

Author Name	Affiliation	E-mail
ZHOU Hai-lin	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China
JIANG Chao-qiang	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China	jcqiang@21cn.com
LAM Tai-hing	香港大学公共卫生学院社会医学系
CHENG Kar-keung	英国伯明翰大学公共卫生与流行病学系
LIU Bin	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China
ZHANG Wei-sen	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China
XU Lin	香港大学公共卫生学院社会医学系
JIN Ya-li	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China
ZHU Tong	The Guangzhou No. 12 People's Hospital, Affiliated to Guangzhou Medical College, Guangzhou 510620, China
Thomas GN	英国伯明翰大学公共卫生与流行病学系

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Abstract:

目的探讨生活习惯及生理生化因素对主动脉弓钙化(AAC)的影响.方法收集"广州生物库队列研究"第一、二期的研究对象20430名,年龄50～85岁的基线资料,体格检查、实验室检查和胸部X线的AAC诊断结果及详细的问卷调查数据;用logistic回归分析某些生活习惯及生理生化因素与AAC患病率之间的关系.结果 (1)2名高级放射诊断医师独立阅片对AAC诊断符合率为85%,Kappa值为0.68(P <0.01),显示AAC诊断是可靠的;(2)除血压外,男女性在某些生理生化特征上有明显差别(P <0.05);(3)年龄、吸烟、LDL-C及高血压是男女性患AAC的危险因素(P <0.01),其OR 值(95%CI):年龄男性为1.11(1.10～1.12),女性1.12(1.12～1.13);吸烟男性为1.31(1.17～1.47),女性1.31(1.09～1.57);LDL-C男性为1.16(1.06～1.27),女性为1.38(1.22～1.56);高血压男性为1.33(1.18～1.50),女性为1.27(1.18～1.38);女性患糖尿病增加患AAC的风险(P <0.001),其OR 值(95%CI)为1.38(1.22～1.56).结论年龄、吸烟、高血压、LDL-C是患AAC的危险因素,糖尿病增加女性患AAC的风险.

English Abstract:

Objective To explore the impact of lifestyle-related,physiological and biochemical factors on aortic arch calcification(AAC).Methods 20 430 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study.All the subjects received face-to-face interviews to collect detailed information on their socio-demographic background,occupational exposures,living environment,lifestyle,family and personal disease histories,and received a physical examination and tests including 12-lead ECG,chest radiograph,and pulmonary function testing.Each subject was screened for a range of fasting biochemical parameters.Radiographs were reviewed by two senior radiologists.300 radiographs were independently read by the two radiologists to assess agreement using Kappa coefficient.Logistic regression was used to assess the association between life style,physiological and biocheroical factors and AAC.Resuits (1)The rate of agreement on diagnosis for the two radiologists was 85% and Kappa coefficient was 0.68(P<0.01) which showed a moderate agreementbetween the two radiologists.(2) Except hypertension,the subjects were significantly difierent on their lifestyle,physiological and biochemical factors in both men and women(P<0.05).(3)AAC was significantly associated with older age,smoking status,LDL-C,and hypertension(P<0.01)in both genders.Ors(95%CI)indicated the following results:age was 1.11(1.10-1.12) in men and 1.12 (1.12-1.13)in women;smoking as 1.31(1.17-1.47)in men and 1.31(1.09-1.57)in women;LDL-Cas 1.16(1.06-1.27) in men and 1.38(1.22-1.56) in women,hypertension as 1.33(1.18-1.50) in men and 1.27(1.18-1.38) in women.However,diabetes was found to be associated with an increased risk of AAC in women[OR(95%CI)]1.38(1.22-1.56). ConclusionAge,smoking,hypertension and Low-density lipoprotcin level were risk factors to beth genders,on AAC,while diabetes increased the risk of AAC,in women.

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