大气污染与脑出血急性发作关系的病例交叉研究

叶瑜; 李秀央; 陈坤; 刘庆敏; 项海青

Abstract

叶瑜,李秀央,陈坤,刘庆敏,项海青.大气污染与脑出血急性发作关系的病例交叉研究[J].Chinese journal of Epidemiology,2009,30(8):816-819

大气污染与脑出血急性发作关系的病例交叉研究

A case-crossover study on the relationship between air pollution and acute onset of cerebral hemorrhage in Hangzhou city

Received:March 06, 2009

DOI：

KeyWord: 脑出血大气污染病例交叉研究

English Key Word: Cerebral hemorrhage Air pollutions Case-crossover study

FundProject:杭州市科技局重点创新项目(20051323B44)

Author Name	Affiliation	E-mail
YE Yu	浙江大学公共卫生学院流行病与卫生统计学系, 杭州, 310058
LI Xiu-yang	浙江大学公共卫生学院流行病与卫生统计学系, 杭州, 310058
CHEN Kun	浙江大学公共卫生学院流行病与卫生统计学系, 杭州, 310058	ck@zju.edu.cn
LIU Qing-min	杭州市疾病预防控制中心
XIANG Hai-qing	杭州市卫生事业发展中心

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Abstract:

目的探讨大气污染与脑出血急性发作的关系.方法应用时间分层病例交叉设计,分析杭州市2002-2004年气溶胶光学厚度(AOD)、可吸入颗粒物(PM₁₀)、二氧化硫(SO₂)和二氧化氮(NO₂)与脑出血急性发作的关系.结果在调整了气象因素后,不同时间段大气污染对脑出血急性发作的滞后期及OR值均不同.AOD每增加1个单位,上半年(滞后2 d)OR=1.727(95%CI:1.103～2.703),春季(滞后2 d)OR=2.412(95%CI:1.230～4.733),其他时间段OR值无统计学意义(P>0.05);SO2每增加10μg/m³,全年(滞后2d)OR=1.119(95%CI:1.019～1.229),上半年(滞后2d)OR=1.230(95%CI:1.092～1.386),春季(滞后2 d)OR=1.254(95%CI:1.076～1.460),其他时间段OR值无统计学意义(P>0.05);NO₂每增加10μg/m³,上半年(滞后2 d)OR=0.841(95%CI:0.734～0.964).其他时间段OR值无统计学意义(P>0.05);PM₁₀各时间段OR值均无统计学意义(P>0.05).结论杭州市大气污染对脑出血急性发作存在影响,尤其是上半年和春季.

English Abstract:

ObjectiveTo explore the relationship bet-ween air pollution and acute onset of cerebral hemorrhage in Hangzhou.Methods Time-stratified case-crossover study was used to analyze the effect of aerosol optical depth(AOD),PM₁₀,SO₂and NO₂on the acute onset of cerebral hemorrhage.Conditional logistic regression was used to estimate the odds ratios(Ors) and their 95% confidence intervals(Cis) in relation to an increase of one unit of AOD and 10 μg/m³of air pollutants.Results After adjusted temperature and relative humidity,the Ors of acute onset of cerebral hemorrhage by a unit increase in AOD at a 2 day-lag were 1.727(95%CI:1.103-2.703)in first half year and 2.412 (95%CI:1.230-4.733) at a 2 day-lag in spring.For a 10 μg/m³increase in SO₂,the Ors were 1.119(95% CI:1.019-1.229),1.230(95%CI:1.092-1.386),1.254(95%CI:1.076-1.460) in the whole year(2 day-lag),in first half year(2 day-lag) and in spring(2 day-lag),respectively.NO₂ exposure in first half year(2 day-lag) was associated with cerebral hemorrhage,with OR as 0.841(95% CI:0.734-0.964).However,there were no statistical significances for AOD,SO₂,NO₂in the rest time-periods(P>0.05).Additionally,no association was found between PM₁₀ and the acute onset of cerebral hemorrhage in any time-periods(P>0.05).Conclusion Our data showed that there was association between air pollution and the acute onset of cerebral hemorrhage,especially in spring and in the first half of the year.

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