钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析

张汝阳; 柏建岭; 易洪刚; 赵杨; 林玉娣; 张铁梅; 陈峰

Abstract

张汝阳,柏建岭,易洪刚,赵杨,林玉娣,张铁梅,陈峰.钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析[J].Chinese journal of Epidemiology,2009,30(8):850-856

钙蛋白酶10基因多态性与2型糖尿病的关联研究:Meta分析

Association between calpain-10 gene polymorphism and risk of type 2 diabetes mellitus:a Meta analysis

Received:March 09, 2009

DOI：

KeyWord: 糖尿病,2型钙蛋白酶10 种族基因多态性分层Meta分析

English Key Word: Diabetes mellitus,type 2 Calpain-10 Race Gene polymorphism Stratified Meta analysis

FundProject:国家"十一五"科技支撑项目(2006BAI02B08)

Author Name	Affiliation	E-mail
ZHANG Ru-yang	Department of Epidemiology and Biostatutws, School of Public Health, Nanjing Medical University, Nanjing 210029, China
BAI Jian-ling	Department of Epidemiology and Biostatutws, School of Public Health, Nanjing Medical University, Nanjing 210029, China
YI Hong-gang	Department of Epidemiology and Biostatutws, School of Public Health, Nanjing Medical University, Nanjing 210029, China
ZHAO Yang	Department of Epidemiology and Biostatutws, School of Public Health, Nanjing Medical University, Nanjing 210029, China
LIN Yu-di	无锡市疾病预防控制中心
ZHANG Tie-mei	卫生部北京医院卫生部北京老年医学研究所
CHEN Feng	南京医科大学公共卫生学院流行病与卫生统计学系, 210029	fengchen@njmu.edu.cn

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Abstract:

目的探讨钙蛋白酶10(CAPN10)基因SNP43、SNP44位点及主要单倍型、单倍型组合与2型糖尿病(T2DM)的关联性.方法根据系统评价的原理和规范,检索PubMed及中文期刊数据库,纳入CAPN10基因与T2DM的病例对照研究.根据种族,采用分层Meta分析评估CAPN10基因多态性与T2DM的关联性.同时评估发表偏倚.结果各种族与T2DM有关联的基因多态性分别是:蒙古人种,SNP43位点G等位基因OR=1.368(95%CI:1.155～1.620),G/G基因型OR=1.437(95%CI:1.186～1.741),111/221单倍型组合OR=2.762(95%CI:1.287～5.927);高加索人种,SNP44位点C等位基因OR=1.144(95%C1:1.023～1.278),111/111单倍型组合OR=1.291(95%CI:1.050～1.586);混血人种,SNP44位点C等位基因OR=1.653(95%CI:1.025～2.665).结论 SNP43位点G等位基因、G/G基因型、111/221单倍型组合是蒙古人种的危险因素;SNP44位点C等位基因、111/111单倍型组合是高加索人种的危险因素;SNP44位点C等位基因是混血人种的危险因素.

English Abstract:

Objective The purpose of this study was to approach the relation of SNP43,SNP44 locus, main haplotypes and haplotype combinations with type 2 diabetes mellitus(T2DM).Methods According to the theory and principles of systematic review,data from case-control studies regarding the association between calpain-10(CAPN10) gene and T2DM were derived through electronic search of PubMed and Chinese journals databases.To gain a more precise estimation of the relationship,a stratified Meta-analysis with four subgroups was pertbrmed according to the races.Publication bias Was also assessed.Results The association with T2DM in different races was evaluated.In Mongoloid race,SNP43-G allele,G/G genotype and 111/221 haplotype combination showed notable association with T2DM with ORs (95%CI) as 1.368(1.155-1.620),1.437(1.186-1.741) and 2.762 (1.287-5.927) respectively.In Caucasoid race,SNP44-C allele,111/111 hapotype combination showed strong relationship with T2DM with Ors(95%CI) as 1.144(1.023-1.278),1.291(1.050-1.586) respectively.In Hybrid race,only one positive finding Was obtained which Was SNP44-C allele with OR(95%CI)as 1.653(1.025-2.665).Conclusion SNP43-G allele,G/G genotype,111/221 were risk factors to Mongoloid race.And SNP-C allele,111/111 haplotype combination were risk factors to Caucasoid race,and SNP44-C allele to Hybrid race.

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