| 魏文,刘盛元,王滨有.Lay Epidemiology:值得关注的流行病学新概念[J].Chinese journal of Epidemiology,2009,30(8):863-864 |
| Lay Epidemiology:值得关注的流行病学新概念 |
| Lay Epidemiology-a new term of epidemiology |
| Received:March 26, 2009 |
| DOI： |
| KeyWord: Lay流行病学 方法 流行病学 |
| English Key Word: Lay Epidemiology Methods Epidemiology |
| FundProject: |
| Author Name | Affiliation | E-mail | | WEI Wen | Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China | | | LIU Sheng-yuan | Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China | | | WANG Bin-you | Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China | wangby42@yahoo.com.cn |
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| Abstract: |
| 1.Lay流行病学的特点:近年来,"Lay Epidemiology"在欧美的流行病学研究报告中频频出现.对于潜在的公共卫生危机,单纯依靠流行病学研究结果而制定防制措施,并不能完全有效阻止疾病发生. |
| English Abstract: |
| Objective To evaluate the value of cervical cytology and hybrid capture Ⅱ (HC-Ⅱ) human papillomavarus (HPV) test for screening cervical lesion. Methods Conventional papanicolaou (Pap) smear by improved take-samples, liquid-based cytology test (LCT) and HC-Ⅱ human papillomavarus test were performed in 425 women in Shang Mei-lin community of Futian region in Shenzhen city, from December 2007 to March 2008 and the above methods were performed in 75 women in Shenzhen Hospital of Peking University at the same time. Age stratified sampling was used. Samples of Pap were taken a broom-type sampling device (take-samples used for LCT) with split-sampling method. Those women with HPV-positive, Pap≥atypical squamous cells of undetermined sign (ASCUS) or LCT≥ASCUS received multi-spot biopsy and endocervical curettage under colposcopy. Final diagnosis would depend on pathological findings as well, to evaluate the values of Pap, LCT, HC-Ⅱ HPV, Pap-HPV parallel test, LCT-HPV parallel test, Pap-HPV serial test and LCT-HPV serial test for the screening program on cervical cancer. Results (1) In this study, 7 women bad cervical intraepithelial neoplasia (CIN) Ⅱ, another 7 had CIN Ⅲ, 1 had cervical cancer in the community; 9 had CIN Ⅱ, 11 had CIN Ⅲ, 3 had cervical cancer in the hospital, respectively. (2) The sensitivity of HC-Ⅱ HPV and cytology-HPV parallel test for detecting≥CIN Ⅱ was >95.0% while negative pre-value were nearly 100.0%. (3) There were no significant differences of screening effectiveness and unsatisfactory rates between Pap of improved take-samples and LCT. (4) The cost-effectiveness ratio of Pap-HPV parallel test was higher than LCT-HPV parallel test. Conclusion It was suggested that the first choice for screening of cervical serious lesion were HC-Ⅱ HPV and cytology-HPV parallel test while Pap-HPV parallel test was the best method for screening purposes. |
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