特发性室速短期暴露危险因素的病例交叉研究

王均琴; 马宁; 高仲阳; 魏永越; 陈峰

Abstract

王均琴,马宁,高仲阳,魏永越,陈峰.特发性室速短期暴露危险因素的病例交叉研究[J].Chinese journal of Epidemiology,2009,30(9):960-963

特发性室速短期暴露危险因素的病例交叉研究

Association between incidence of idiopathic ventricular tachycardia and risk factors withshort-term effects：a case-crossover study

Received:February 07, 2009 Revised:December 06, 2007

DOI：

KeyWord: 特发性室速危险因素病例交叉研究广义估计方程

English Key Word: Idiopathic ventricular tachycardia Risk factor Case-crossover study Generalized estimating equation

FundProject:国家自然科学基金(30571619)

Author Name	Affiliation	E-mail
WANG Junqin	Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University. Nan]ing 210029, China
MA Ning	江苏省人民医院心内科
GA0 Zhongyang	东南大学附属医院心内科
WEI Yongyue	Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University. Nan]ing 210029, China
CHEN Feng	Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University. Nan]ing 210029, China	fengchen@njmu．edu．cn

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Abstract:

目的探索特发性室速(ⅣT)短期暴露的危险因素。方法采用病例交叉设计，通过广义估计方程对2007年11月1日至2008年12月31日期间江苏省人民医院和东南大学附属医院ⅣT病例和短期暴露危险因素之间的联系进行分析。结果多因素分析结果显示的危险因素有强体力活动(OR=2．20，95％CI：1．51～3．19)、生气(OR=1．87，95％CI：1．07-3．27)、悲伤(OR=3．58，95％c，：2．19～5．84)、激动(OR=3．06，95％CI：1．61～5．83)、感染(OR=2．25，95％C／：1．44～3．50)。结论强体力活动、生气、悲伤、激动、感染是ⅣT的危险因素。病例交叉研究能有效地识别，并揭示其作用强度。

English Abstract:

0bjective To explore the transient risks regarding idiopathic ventriculartachycardia(IVT)．Methods A symmetric bidirectional case．crossover design was used to estimate the short-term risk of IVT．In the case-crossover design each case served as its own mar：hed control while case．period were compared to two contr01．periods．7 days before and after the case-period． Ninety．four subiects were recruited from People’S Hospital of Jiangsu Province and Affiliated Hospital of Southeast University from Dec．2007 to NOV．2008．Generalized estimating equation．with binomial distributed dependent variable and logit link．function．was used to estimate 0R and 95％C／．Results 111e risk factors that were associated withⅣT WOUId include：physical exertion(0R=2．20，95％(Y：1．5l一3．19)，in the state of anger(0R=1．87，95％CI：1．07-3．27)sad feelings(0R=3．58，95％CI：2．19-5．84)，or agitation(OR=3．06，95％C7：1．61-5．83)and having infection of some kind(OR=2．25。95％c，：1．44-3．50)．Conclusion Factors as physical Exertion。in the mood of anger．sadness agitation．having some kind of infection were related to IVT．Case-crossover design seemed to be able to identify the risk factors of IVT and its intensity．

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