| 孙军玲,张静.手足口病流行病学研究进展[J].Chinese journal of Epidemiology,2009,30(9):973-976 |
| 手足口病流行病学研究进展 |
| renew OR the advancement of epidemiology 011 handfoot-mouth disease |
| Received:February 26, 2009 Revised:October 25, 2007 |
| DOI： |
| KeyWord: 手足口病 流行病学 |
| English Key Word: Hand-foot-mouth disease Epidemiology |
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| Abstract: |
| 手足口病(hand．foot-mouth disease)是世界范围内流行的儿童常见病，可由多种病毒感染引起，以发热和手、足、口腔等部位出现皮疹或疱疹为主要特征。少数患儿可出现脑炎、急性弛缓性麻痹、脑水肿和心肌炎等严重并发症。病情进展快，易发生死亡。近十多年来，手足口病在许多国家和地区，特别是亚太地区发生过多次较大规模的暴发或流行，引起一定数量儿童的死亡，越来越受到各国的关注。众多研究表明，感染病毒的类型决定了疾病的严重程度，肠道病毒71型(EV71)较其他病毒毒株更易导致出现重症病例，甚至死亡病例。 |
| English Abstract: |
| Objective To study the risks on acute cerebral stroke(ACS ) inducing systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome(MODS ).Methods Data from 1751 patients with acute cerebral stroke were studied by prospective analysis. Results In all of the ACS patients, the incidence rate(IR) of SIRS was 36.50% with 2fl5 patients having ACS inducing MODS, to which the IR was 11.71%，and 93 deaths. The case fatality ratio ( CFR ) was 45. 37%The
pathogeneses condition of patients and the MR after the occurrence of MODS had positive correlation with the numbers of dysfunction organs. Study on single factor analysis revealed that the incidence of MODS had some related risk factors in the ACS inducing MODS, including age, diseased region close to the mean line, GCS,level of blood sugar, blood white cell count and the chronic disease history etc. The 1R of ACS inducing SIRS and MODS was much higher in the condition of the diseased region near the mean line and
the ACS of the basilar artery system. Conclusion SIRS seemed the base for MODS while the probability and the development degree were not only involved ACS but also SIRS. MODS induced by ACS could be reduced through the second grade program of disease precaution. The detection of those risk factors in the early period of the ACS course could provide some prediction of the prognosis and turnover, thus some early use of intervention methods might be helpful in the treatment of the disease. |
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