诺如病毒GG I、GGⅡ型混合感染致胃肠炎饮水型暴发调查

顾时平; 张宏; 胡雪根; 张喜琴; 游继存; 黄艺

Abstract

顾时平,张宏,胡雪根,张喜琴,游继存,黄艺.诺如病毒GG I、GGⅡ型混合感染致胃肠炎饮水型暴发调查[J].Chinese journal of Epidemiology,2009,30(10):1033

诺如病毒GG I、GGⅡ型混合感染致胃肠炎饮水型暴发调查

A case-crossover study on the relationship between air pollution and acute onset of cerebral hemorrhage in Hangzhou city

Received:March 06, 2009

DOI：

KeyWord: 脑出血大气污染病例交叉研究

English Key Word: Cerebral hemorrhage Air pollutions Case-crossover study

FundProject:杭州市科技局重点创新项目(20051323B44)

Author Name	Affiliation
GU Shi-ping	浙江省安吉县疾病预防控制中心 313300
ZHANG Hong	浙江省安吉县疾病预防控制中心 313300
HU Xue-gen	浙江省安吉县疾病预防控制中心 313300
ZHANG Xi-qin	浙江省安吉县疾病预防控制中心 313300
YOU Ji-cun	浙江省安吉县疾病预防控制中心 313300
HUANG Yi	浙江省安吉县疾病预防控制中心 313300

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Abstract:

诺如病毒是引起人类急性胃肠炎的重要病原体,基因型包括GG Ⅰ、GG Ⅱ、GGⅣ~([1]).混合基因型引起感染较少.2009年2月浙江省安吉县某学校发生一起诺如病毒GGI、GGⅡ型混合感染暴发疫情.使用统一调查表对该校疫情流行期间的腹泻学生进行流行病学调查核实,出现腹泻(≥3次/d)或呕吐伴腹泻、恶心、腹胀、头晕等症状之一者作为胃肠炎病例;采集部分病例粪便标本,用Real Time RT-RCR方法检测病毒基因型.通过描述性研究进行流行特征分析;通过病例对照研究进行病因探索,按1:3频数匹配随机选择病例24例、对照72人;通过计算OR值、χ~2值判断可能的暴露因素.

English Abstract:

ObjectiveTo explore the relationship bet-ween air pollution and acute onset of cerebral hemorrhage in Hangzhou.Methods Time-stratified case-crossover study was used to analyze the effect of aerosol optical depth(AOD),PM₁₀,SO₂and NO₂on the acute onset of cerebral hemorrhage.Conditional logistic regression was used to estimate the odds ratios(Ors) and their 95% confidence intervals(Cis) in relation to an increase of one unit of AOD and 10 μg/m³of air pollutants.Results After adjusted temperature and relative humidity,the Ors of acute onset of cerebral hemorrhage by a unit increase in AOD at a 2 day-lag were 1.727(95%CI:1.103-2.703)in first half year and 2.412 (95%CI:1.230-4.733) at a 2 day-lag in spring.For a 10 μg/m³increase in SO₂,the Ors were 1.119(95% CI:1.019-1.229),1.230(95%CI:1.092-1.386),1.254(95%CI:1.076-1.460) in the whole year(2 day-lag),in first half year(2 day-lag) and in spring(2 day-lag),respectively.NO₂ exposure in first half year(2 day-lag) was associated with cerebral hemorrhage,with OR as 0.841(95% CI:0.734-0.964).However,there were no statistical significances for AOD,SO₂,NO₂in the rest time-periods(P>0.05).Additionally,no association was found between PM₁₀ and the acute onset of cerebral hemorrhage in any time-periods(P>0.05).Conclusion Our data showed that there was association between air pollution and the acute onset of cerebral hemorrhage,especially in spring and in the first half of the year.

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