| 郭炳虹,肖朋,徐伟,崔树峰,马建新,李书明.北京市朝阳区居民传染病漏报调查分析[J].Chinese journal of Epidemiology,2009,30(10):1059 |
| 北京市朝阳区居民传染病漏报调查分析 |
| Meta-analysis on the association of G894T polymorphism in endothelial nitric oxide synthase gene and essential hypertension in Chinese population |
| Received:March 23, 2009 |
| DOI： |
| KeyWord: 高血压 内皮型一氧化氮合酶 Meta分析 |
| English Key Word: Hypertension Endothelial nitric oxide syathase Meta-analysis |
| FundProject:北京市优秀人才培养项目 |
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| Abstract: |
| 为进一步了解和掌握北京市朝阳区居民传染病报告的现状,推算出比较接近实际的发病水平,于2008年开展了居民传染病漏报调查. |
| English Abstract: |
| Objective To evaluate the relationship between G894T(Glu298Asp) polymorphism in the endothelial nitric oxide synthase (eNOS)gene and essential hypertension in Chinese population from difierent regions.Methods Odds ratios(ORs) of G894T genotype and allele distributions in essential hypertension patients against healthy controls were analyzed.All the relevant studies were screened with poor-qualified studies eliminated.Meta-analysis software MIX(Meta-analysis with interactive explanations-version 1.71),was applied for investigating and analyzing heterogeneity among individual studies and summarizing the effects across studies,and the risk of publication bias was evaluated.Results A total of 1900 cases and 1216 controls from 10 studies were included.The heterogeneity between studies Was significant(P=0.013;P=0.011) and there were substantial sources of Publication bias(P=0.049;P=0.038).The pooled OR(with 95% CI) of GT+TT vs.GG genotype was 1.79(1.33-2.42)(Z=3.83,P<0.001),and the pooled OR (with 95% CI) of T vs.G allele Was 1.73(1.32-2.27)(Z=3.92,P<0.001).Conclusion In Chinese population,mainly the Hans ethnic group,894G→T mutation in the eNOS appeared to be related to essential hypertension. |
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