| 折潇,屈秋民,王锐利,曹红梅,乔晋,郭峰.西安地区92例帕金森病患者药物治疗情况调查[J].Chinese journal of Epidemiology,2009,30(10):1065-1068 |
| 西安地区92例帕金森病患者药物治疗情况调查 |
| The use of antiparkinsonism drugs in 92 cases in Xi' an city |
| Received:April 24, 2009 |
| DOI： |
| KeyWord: 帕金森病 药物治疗 流行病学 |
| English Key Word: Parkinson's disease Drug treatment Epidemiology |
| FundProject:西安市科学技术计划 |
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| Abstract: |
| 目的 了解西安地区帕金森病(PD)患者药物治疗情况.方法 随机抽取西安地区6家综合医院,采用竞争入组法收集研究期间各医院门诊就诊的PD患者,进行面对面问卷调查.结果 共入组PD患者92例,其中男48例,女44例;年龄43～86岁(65.6岁±17.1岁),病程0.2～27.8年(4.4年±9.4年).不同首发症状患者间首选药物的差异无统计学意义(P>0.05).发病年龄<65岁且认知功能正常者45例;发病年龄≥65岁且伴/或不伴有痴呆者47例,两组首选药物的差异无统计学意义(P>0.05).不同严重程度PD患者调查时用药方案的差异无统计学意义(P>0.05).55.3%的患者治疗中随意调整PD治疗药物,调整用药与患者性别、年龄、受教育水平、痴呆、家庭人口数、病程、Hoehn & Yahr分级、每日服药次数、服药种类等无明显关系.结论 西安地区PD治疗不规范,且很少使用多巴胺受体激动剂,半数以上患者随意调整治疗药物. |
| English Abstract: |
| Objective To investigate the treatment status of antiparkinsonism in Xi'an. Methods Six general hospitals were randomly chosen in Xi' an and all Parkinson' s disease (PD) patients were interviewed by questionnaire from Jan. 2007 to Apr. 2007. Results 92 PD outpatients were enrolled in, including 48 males and 44 females, from 43 to 86 years old (mean 65.6±17.1) with duration of the disease from 0.2 to 27.8 years (mean 4.4 ±9.4). The preference of the drug use from the patients were: 40 (43.5%) preferred taking levodopa, 25 (27.2%) with amantadine and/or trihexyphenidyl, 14(15.2%) with levodopa and others, 4(4.4%) with dopamine agonist and others, 2 (2.2%) with other drugs, 7 (7.6%) with no treatment. There were 69 (75.0%) patients onset with resting tremor, 15 (16.3%) with bradykinesia, 6 (6.5%) with rigidity, and 2 (2.2%) with unknown symptoms. There was no startically significant difference in anti-PD drugs among the patients onset with different symptoms (P>0.05). 45 patients appeared the onset of disease before 65 years old and with no dementia, 47 onset after 65 with or without dementia. There was no significant difference of anti-PD drugs between the two groups (P>0.05). Most patients initiated anti-PD treatment with levodopa but few of them chose dopamine agonist. According to the classification of Hoehn & Yahr, 25(27.2%) belonged to Grade Ⅰ, 53(57.6%) to Grade Ⅱ,8(8.7%) to Grade Ⅲ,3(3.3%) to Grade Ⅳ and 3 (3.3%) to Grade Ⅴ. There was no significant differences of anti-PD drugs between different grades of the disease (P>0.05). 55.3% of the patients changed their anti-PD drugs randomly during the therapy, but with no relation to their gender, age, educational level, dementia, the number of family members, course of diseases, or the degree of Hoehn & Yahr, frequency and categories of medicine. Conclusion Anti-PD treatment in Xi' an did not strictly follow the standardized protocol, with few patients using dopamine agonist and over 50% of the patients changed their drugs randomly. |
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