| 梁明斌,胡永华,武轶群.表观遗传流行病学——新兴流行病学分支学科[J].Chinese journal of Epidemiology,2009,30(10):1078-1080 |
| 表观遗传流行病学——新兴流行病学分支学科 |
| Emergence of a new branch on epidemiology: Epigenetic epidemiology |
| Received:February 23, 2009 |
| DOI： |
| KeyWord: 表观遗传 流行病学 |
| English Key Word: Epigenetic inheritance Epidemiology |
| FundProject:国家自然科学基金 |
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| Abstract: |
| 2001年与2007年著名杂志Science和Nature围绕表观遗传学分别发表专题,阐述了表观遗传学的相关理论和应用前景~([1,2]).近年来众多流行病学家应用表观遗传学理论,开展了较多的探索与研究. |
| English Abstract: |
| Objective To study the morbidity of cough variant asthma (CVA) among patients with chronic cough syndrome and its relative risk factors.Methods Patients were recruited with detailed history on their illness. Data were collected on physical examination, chest X-ray, eosinophil cell counts, pulmonary ventilation with histamine stimulating test and bronchi dilation test. According to available data, diagnosis of CVA was confirmed and the relative factors Questionnaire form was completed for each patient.Results Among 473 patients with chronic cough, 95 (44 male and 51 female) were confirmed to be CVA (20.08%). Analysis of the relative factors suggested that CVA was associated with multiple factors. Morbidity of CVA was associated with season, personal histories on allergy and family history on asthma, CVA could be induced by upper respiratory tract infection, inhale of oil vapor, acrimony air, over-burdened physical exercises etc.Conclusion For patients with chronic cough symptom, clear diagnosis of CVA, avoid of passable risk factors and timely medical intervention when necessary, would be helpful in controlling clinical courses and improving the prognosis of the disease. |
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