| 许华斌,汪兴太,庄辉.美国狂犬病的预防策略与挑战[J].Chinese journal of Epidemiology,2009,30(10):1081-1083 |
| 美国狂犬病的预防策略与挑战 |
| Rabies prevention strategies and challenges in the United States |
| Received:February 28, 2009 |
| DOI： |
| KeyWord: 狂犬病 预防策略 疫苗接种 |
| English Key Word: Rabies Prevention strategies Vaccination |
| FundProject:美国中华医学基金会(CMB) |
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| Abstract: |
| 狂犬病是由狂犬病毒所导致的人畜共患疾病.欧美国家的狂犬病流行毒株包括犬株、蝙蝠株和浣熊株等~([1]).美国在第二次世界大战后,通过对宠物犬疫苗接种和野犬等的有效控制,人畜狂犬病的病例数显著下降.1946年,美国报告8384只病犬狂犬病和33例人狂犬病确诊病例. |
| English Abstract: |
| Objective To investigate the efficacy and safety of ezctimibe on uncontrolled LDL-C when added to ongoing statin therapy in patients with coronary heart diseases (CHD) and diabetes mellitus (DM). Methods 61 patients with LDL-C level exceeding target goal (<2.07 mmol/L) after 12 weeks' treatment with statins, received ezetimibe in addition to their ongoing statin therapy for 8 weeks. Lipid parameters, alanine aminotransferase(ALT), aspartic aminotransferase(AST) and ereatine kinase(CK) were compared before and after the adding of ezetimibe. Results LDL-C before and after the adding of ezetimibe was (2.74±0.43) mmol/L and (2.19±0.32) mmol/L, respectively (P=0.03) in 61 patients. Ezetimibe added to statin therapy significantly reduced the LDL-C level and TC level by additional 20.1% and 19.1%, respectively (P<0.05). 74%(45/61) patients treated with ezetimibe added to statin reached their target LDL-C goal. No change of TG and HDL-C was observed and no change of AST, ALT and CK was found either. Conclusion Ezetimibe added to statin therapy lowered LDL-C level further and improved the goal attainment in patients with CHD and DM. |
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