云南省某县HIV感染者Ⅱ型单纯疱疹病毒感染及高危性行为研究

傅卓华; 高眉扬; 陈莉; 康永然; 杨建华; 何纳

Abstract

傅卓华,高眉扬,陈莉,康永然,杨建华,何纳.云南省某县HIV感染者Ⅱ型单纯疱疹病毒感染及高危性行为研究[J].Chinese journal of Epidemiology,2009,30(11):1139-1142

云南省某县HIV感染者Ⅱ型单纯疱疹病毒感染及高危性行为研究

Study on herpes simplex virus 2 infection and risky sexual behavior among HIV-infected patients in a county of Yunnan province

Received:March 06, 2009

DOI：

KeyWord: 艾滋病病毒感染 Ⅱ型单纯疱疹病毒高危性行为

English Key Word: uman immtmodeficiency virus infection Herpes simplex virus 2 infection IUsky sexual behavior

FundProject:上海市重点学科建设项日(BI 18)

Author Name	Affiliation	E-mail
FU Zhao-hua	Department of Epidemiology School of Public Health, Fudan University, Shanghai 200032, China
GAO Mei-yang	Department of Epidemiology School of Public Health, Fudan University, Shanghai 200032, China
CHEN Li	Department of Epidemiology School of Public Health, Fudan University, Shanghai 200032, China
KANG Yong-ran	云南省盈江县疾病预防控制中心
YANG Jian-hua	云南省盈江县疾病预防控制中心
HE Na	Department of Epidemiology School of Public Health, Fudan University, Shanghai 200032, China	nhe@shmu.edu.cn

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Abstract:

目的了解云南省某县HIV感染者中Ⅱ型单纯疱疹病毒(Hsv-2)感染率、HSV-2感染相关闪素及高危性行为情况.方法从常规随访的HIV感染者中招募研究对象,问卷调查收集人口学、行为学信息,采集血标本检测HSV-2抗体和CD^{4⁺T淋巴细胞计数.结果共招募研究对象300人,其中105人检测为HSV-2抗体阳性,感染率为35.0%.多因素logistic回归模型显示,傣族(OR=0.300,95%CI:0.152～0.593)和景颇族(OR=0.376,95% CI:0.167-0.850)HIV感染者HSV-2感染风险低于汉族|经性途径感染HIV者HSV-2感染风险高于经注射吸毒感染HIV者(OR=4.244,95%CI:1.924- 9.364).105人合并感染HIV和HSV-2,其中60人最近3月内有性行为,未坚持使用或不使用安全套者占有性行为者的41.7%,主要见于婚内性行为.结论HIV感染者中HSV-2感染率较高,HIV/HSV-2合并感染者中有不安全性行为者比例高.}

English Abstract:

Objective To explore the sere-prevalence and risk factors for herpes simplex vires 2(HSV-2)infection and unprotected sexual behavior in an ethnically diverse population of HIV-infected subjects in a county of Yunnan province.Methods HIV-infected individuals attending for routine follow-up by local Center for Disease Centrel and Prevention(CDC)were recruited to participate in the study under'informed consent'.A face-to-face questionnaire interview was administered to each participant.Blood was drawn for HSV-2 testing by HerpeSelect HSV-2 ELISA(Focus Diagnostics)and CD₄⁺T counting.Results A toml of 300 HIV-infected individuals participated in the study.The mean age of the subjects was 37.6 years with 76.7%as males.Ethnically, Hun, Dai and Jingpo accounted for 44.3%, 37.3%and 1 6.0%of the sample, respectively.Half of the subjects reported HIV acquisition through injection drug use.The sero-prevalence of HSV-2 was 35.0%. Results from multiple logistic regression analysis indicated that individuals who acquired HIV through heterosexual contact were more likely to be HSV-2 positive than those who acquired HIV through injection drug use(0R=4.244, 95%CI：1.924-9.364), whereas Dai(OR=0.300, 95%CI：0.152-0.593)and Jingpo(OR=0.376.95% CI：0.167-0.850)were less likely to be HSV-2 positive than the Hans.Among l 05 people who were co-infected with HIV/HSv-2.60 had sexual intercourses in the past 3 months and 4 1.7% of them reported no or jnconsistent USe of condoms.Most unprotected sexuaI contacts occurred within married couples.Conclusion HSV-2 infection was highly prevalent among HIV-infccted individuals in this county.and a significant proportion of HIV/HSV-2 co-infected subjects engaged in unprotected sex.HSV-2 testing.behavioral and biomedical interventions among HIV-infected individuals and their sexual partners should be involved in the local HIV-prevention and centreI programs.

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