脂质蓄积指数和体重指数与糖尿病关系比较的前瞻性研究

杨晨; 郭志荣; 胡晓抒; 周正元; 武呜

Abstract

杨晨,郭志荣,胡晓抒,周正元,武呜.脂质蓄积指数和体重指数与糖尿病关系比较的前瞻性研究[J].Chinese journal of Epidemiology,2010,31(1):5-8

脂质蓄积指数和体重指数与糖尿病关系比较的前瞻性研究

A prospective study on the association between Hpid accumulation product or body mass index and tfiabetes

Received:August 10, 2009

DOI：

KeyWord: 糖尿病脂质蓄积指数体重指数前瞻性研究

English Key Word: Diabetes Lipid accumulation product index Body mass index Prospective study

FundProject:卫生部科学研究基金(WKJ2004—2—014)

Author Name	Affiliation	E-mail
YANG Chen	Department of Radiology&Public Health, Soochow University, Suzhou 215123, China
GUO Zhirong	Department of Radiology&Public Health, Soochow University, Suzhou 215123, China	guozhiron928@163.com
HU Xiaoshu	Health Bureau of Jiangsu Province
ZHOU Zhengyuan	Changshu Center for Disease Control and Prevention
WU Ming	Jiangsu Provincial Center for Disease Control and Prevention

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Abstract:

目的探讨基线脂质蓄积指数(LAP)与体重指数(BMI)不同水平与随访糖尿病(DM)发病的关系。方法运用前瞻性研究方法，以江苏省多代谢异常和代谢综合征(Ms)防治队列研究人群为研究对象，分析并比较基线LAP和BMI不同水平与DM的关系，计算LAP、BMI、腰围(WC)、腰臀比(WHR)对预测随访DM的ROC曲线下面积。结果与BMI相比，不论男女DM发病人数及累计患病率随LAP水平增高而增加的趋势更为明显；调整年龄、DM一般危险因素后，相对危险度(BR)分别随BMI水平和LAP水平增加而增高，但后者更具有统计学意义(P<0.05)；4种肥胖指标中，预测随访DM的ROC曲线下面积从大到小依次为LAP、WHR、WC、BMI。结论高u心比高BMI更容易导致DM；相对于体重增加，DM的形成可能与体内脂质蓄积关系更为密切。

English Abstract:

Objective To measure the association between lilDlid accumulation product(LAP)or body mass index(BMI)and diabetes.Methods In this prospective study。subjects wererecruited and followed up for more than five years from the program“Prevention of MultipleMetabolic Disorders and MS in Jiangsu Province”(PMMJS).A total number of 3598 people pattieipating in the follow.up program，with complete information.Incidence rates of diabetes and relative risk in different levels of LAP and BMl were compared and analyzed.Areas under the receiver operation characteristic calve for obesity indicators such as LAP，BMI，waist circumference(WC)，waist.to.hip ratio(WHR)in predicting diabetes of cohort population were calculated.Results The number and the cumulative incidence of diabetes increased with the LAP levels in both men and women.After adjusting for age and other traditional risk factors Oll diabetes，the adjusted risk ratios(aRR)value ofdiabeteswere 4.33(134—14.01)formenand 5.04(2.06—12.34)forwomen，between the highest and the lowest level of LAP groups.When further adjusted for BMI.the aRR value decreased to 3.15(1.13—8.80)for men and 4.84(2.16—10.84)for women.The number and the cumulative incidence of diabetes also increased with the B~Ⅱlevels in botIl men and women but not significantly as the LAP showed.and the时己R values were 1.34(O.61—2.93)for men and 1.69 (0.91—3.06)for women in the highest level of BMI group，when compared with the lowest level group.Again。when further adjusted for LAP，the aRR values decreased to 1.23(0.59—2.69)for men and 1.39(0.74-2.60)for women.The area under the ROC calve(AUC)for the four kinds of obesity indicators in predicting diabetes in the descending order were LAP，WHR，WC，BMI in both men and women.Conclusion LAP seemed more associated to diabetes than to BMI.When comparing with weight gain，diabetes might be more closely associated with the lipid accumulation product.

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