| 张荣莲,罗颖,谢婧娴,陈起燕,成玲,郭胜斌,黄欣欣.HBV父婴垂直传播水平与HBV-DNA载量的相关研究[J].Chinese journal of Epidemiology,2010,31(2):159-162 |
| HBV父婴垂直传播水平与HBV-DNA载量的相关研究 |
| A correlation analysis between the rate of vertical transmission of丑BV and HBsAg.positive father to infant and the rate of neonatal cord blood HBV.DNA |
| Received:June 16, 2009 |
| DOI： |
| KeyWord: 乙型肝炎病毒 乙型肝炎病毒一脱氧核糖核酸 传播，父婴垂直 |
| English Key Word: Hepatitis B vinls Hepatitis Bvirus-DNA Vertical transmission |
| FundProject: |
| Author Name | Affiliation | E-mail | | ZHANG Rong-lian | Fujian Provinciat Maternal and Child Health Hospital, Fuzhou 35000l, China | wpxzrl@163.com | | LU0 Ying | Fujian ProvinciaZ Health Department Training Center | | | XlE Jing-xian | Department ofObstetrics and Gynecology, Fuiian Medical Unwershy | | | CHEN Qi-yan | Fujian Provinciat Maternal and Child Health Hospital, Fuzhou 35000l, China | | | CHENG Ling | Fujian Provinciat Maternal and Child Health Hospital, Fuzhou 35000l, China | | | GUO Sheng-bin | Fujian Provinciat Maternal and Child Health Hospital, Fuzhou 35000l, China | | | HUANG Xin-xin | Fujian Provinciat Maternal and Child Health Hospital, Fuzhou 35000l, China | |
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| Abstract: |
| 目的探讨HBsAg阳性父亲血HBV-DNA的不同载量水平对其新生儿发生HBV父婴垂直传播的影响。方法对161例HBsAg阳性的父亲及其新生JL(母亲m清HBVlvl全阴性或仅HBsAb阳性及HBV-DNA均为阴性)HBV感染状况进行调查分析。采用ELISA检测HBVM，FQ-PCR法检测血清I-IBV DNA载量水平。结果(1)父亲血HBV-DNA载量水平与新生儿脐带血HBV DNA阳性存在剂量反应关系趋势(χ2=64.117，P=0.000)。父亲血HBV-DNA≥1.0×107copies/ml组新生儿的HBV父婴垂直传播水平显著高于<1.0×107 copies/ml组(χ2=71.539，P=0.000)；(2)HBeAg阳性组与HBeAg阴性组父亲其新生儿的HBVoDNA阳性率差异有统计学意义(χ2=6.892。P=0.009)。结论父亲血清HBV-DNA载量水平与是否发生HBV父婴垂直传播密切相关，随血清HBV-DNA载量增加而上升，并存在影响传播的浓度界面；父亲血清HBV-DNAI>1.0×107 copies/ml及HBeAg阳性是HBV父婴垂直传播的危险因素。 |
| English Abstract: |
| Objective To study the influence of HBV二DNA with different 10ad levels of HBsAg-positive among fathers on the rate of neonatal cord blood HBV二DNA.Methods Using HBsAg and HBV二DNA as screening indicators for pregnant women and their husbands from all obstetric clinic.161 pregnant women whose HBsAg and HBV二DNA were negative.but HBsAg Was positive among their husbands and their newborns.were selected.BIood samples from those pregnant women，their husbands and their newborns were collected to detect the related indicators.Using ELISA to detect hepatitis B virus markers(HBVM).and FQ.PCR to detect the levels of HBV二DNA load.According to neonatal cord blood HBV二DNA detection guideline.newborns with cord blood HBV-DNA positive were selected as cases。others as controls.Results (1)Result of the study showed that there Was a dose-response relationship between patemal serum HBV二DNA load levels andneonatal cordbloodHBv-DNApositiveratesinnewborns(trendY2=64.117，P=O.000).Therate of vertical transmission of HBV from HBsAg-positive father to infant in the paternal serum HBV二DNA≥1.O×107 copies/ml group WaS significantly higher than HBV二DNA<1.O×107 copies/ml group(X2=71.539，P=0.000).(2)There Was a positive rank correlation between semen positive HBeAg and vm'tical transmission of HBV from HBsAg.positive father to infant(z 2=6.892，P=0.009).Conclusion There was a dose-response relationship between patemal serum HBV二DNA load levels and neonatal cord blood HBV二DNA positive in newborns.Patemal serum HBV-DNA≥1.O×107 copies/mI and with HBeAg positive status were risk factors ofvertical transmission ofHBVfrom HBsAg.positive father to infant. |
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