| 王凡,叶平,肖文凯,骆雷鸣,吴红梅.北京部分地区人群心血管疾病危险因素与慢性肾脏病的相关性分析[J].Chinese journal of Epidemiology,2010,31(3):256-259 |
| 北京部分地区人群心血管疾病危险因素与慢性肾脏病的相关性分析 |
| Association of risk factors for cardiovascular disease and the rate of glomerular filtration: a cross-sectional study in the population from certain areas of Beijing |
| Received:September 16, 2009 |
| DOI： |
| KeyWord: 慢性肾脏病 心血管疾病 危险因素 |
| English Key Word: Chronic kidney disease Cardiovascular disease Risk factors |
| FundProject: |
| Author Name | Affiliation | E-mail | | 王凡 | Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China | | | 叶平 | Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China | yeping@sina.com | | 肖文凯 | Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China | | | 骆雷鸣 | Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China | | | 吴红梅 | Department of Geriatric Cardiology, The Chinese PLA General Hospital, Beijing 100853, China | |
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| Abstract: |
| 目的 探讨一般人群中传统心血管疾病危险因素与慢性肾脏病的相关关系.方法 2007-2008年随机对北京部分地区5100名成年人进行估计肾小球滤过率(eGFR)水平及心血管疾病危险因素的横断面调查,4515名符合入选标准并对其资料进行分析.设计统一的心血管疾病危险因素调查表,进行心血管疾病传统危险因素现况调查,测量身高、体重、血压,检测TC、TG、LDL-C、HDL-C及肌酐(Scr)指标,用简化的MDRD公式估算GFR(eGFR),并以eGFR[ml·min(-1)·(1.73 m2)(-1)]<60定义为慢性肾脏病(CKD).按eGFR≥90、60-89和<60将人群分为3组,采用单因素方差分析进行组间均值的比较,X~2检验进行组间率的比较,以有无CKD为因变量(eGFR≥60为0,eGFR<60为1),以所选择的研究因素为自变量,进行单因素及多因素logistic回归分析.结果随着eGFR水平下降,心血管疾病危险因素检出率增加;单因素分析显示,年龄、吸烟情况、高血压及糖尿病病史、BMI、SBP、LDL-C及TG是CKD的危险因素,女性是其保护性因素;多因素分析表明,增龄、吸烟、高血压、高TG是CKD的重要危险因素,OR值(95%CI)分别为1.80(1.28～2.52)、1.09(1.06～1.13)、2.50(1.75～3.57)、1.73(1.18～2.54),而女性是其保护性因素.结论 北京地区一般人群心血管疾病危险因素随eGFR水平下降检出率增高,年龄、血压、TG、吸烟是CKD的危险因素. |
| English Abstract: |
| Objective Data from several large prospective studies revealed that a low glomerular filtration rate was independently associated with cardiovascular disease (CVD) events and all-cause mortality in high-risk populations. Much on the association was explained by traditional CVD risk factors. However,findings from population-based studies were scarce and inconsistent. We explored the correlation between risks factors of cardiovascular and chronic kidney disease (CKD) in a general population from certain area of Beijing. Methods A population-based cross-sectional survey was conducted during Sep. 2007 to Oct. 2008 in Beijing. Out of 5100 individuals who were selected,4515 met the inclusion criteria and responded to the investigation. By face to face interview,a questionnaire was used to find out the risk factors of cardiovascular disease. Body height,body weight and blood pressures were measured. Serum creatinine and total cholesterol (TC),triglyceride (TG),low-density lipoprotein cholesterol (LDL-C),high-density lipoprotein cholesterol (HDL-C) were detected. Glomerular filtration rate through using the Modification of Diet in Renal Disease equation was estimated.Participants were grouped into three:≥90,60-89,<60[ml·min~(-1)·(1.73m~2)~(-1)] by eGFR. Univariate and multivariate logistic regression models were used to identify the associated risk factors.Results Exposure rate of cardiovascular disease risk factors increased along with the decrease of level of eGFR. Data from univariate logistic regression analyses suggested that age,smoking,history of hypertension and diabetes,BMI,SBP,LDL-C and TG were risk factors of CKD while results from multiple logistic regression indicated that age,smoking,hypertension,high level of TG appeared to be independent risk factors of CKD. Conclusion Exposure rate of cardiovascular disease risk factors increased along with the decrease of level of eGFR while age,hypertension,high level of TG and smoking were independent risk factors of CKD. |
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