| 李东民,王璐,高省,王哲,崔兆麟,宋鲁平,何文生,王水旺,陈长宽,汪宁.中国中部地区经不安全采供血感染艾滋病毒的自然病程研究[J].Chinese journal of Epidemiology,2010,31(6):633-637 |
| 中国中部地区经不安全采供血感染艾滋病毒的自然病程研究 |
| Study on the natural history of HIV among former commercial plasma donors caused by contaminated plasma donation in central China |
| Received:December 28, 2009 |
| DOI：10.3760/cma.j.issn.0254-6450.2010.06.007 |
| KeyWord: 艾滋病 既往有偿献血人员 自然病程 队列研究 |
| English Key Word: HIV/AIDS Former commercial plasma donors Natural history Cohort study |
| FundProject:国家"十五"科技攻关课题(2004BA719A02) |
| Author Name | Affiliation | E-mail | | LI Dong-min | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | WANG Lu | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | GAO Xing | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | | | WANG Zhe | Henan Provincial Center for Disease Control and Prevention | | | CUI Zhao-Lin | Henan Provincial Center for Disease Control and Prevention | | | SONG Lu-pin | Zhumadian Center for Disease Control and Prevention | | | HE Wen-sheng | Zhumadian Center for Disease Control and Prevention | | | WANG Shui-wang | Shangcai Center for Disease Control and Prevention | | | CHEN Chang-kuang | Shangcai Center for Disease Control and Prevention | | | WANG Ning | National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China | wangnbj@163.com |
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| Abstract: |
| 目的 研究中国经不安全采供血感染艾滋病毒(HIV)的发病、死亡自然病程.方法 采用双向性队列研究方法,选择河南省上蔡县既往有偿献血员较为集巾的7个村庄中明确诊断为HIV感染者/艾滋病患者(HIV/AIDS)或疑似AIDS死亡者,收集其发病、死亡及治疗等信息.观察终点为2008年3月31日.用乘积积限法计算艾滋病潜伏期和生存时间,对结局事件的时点进行调整分析.结果 2569例既往有偿献血员HIV感染者,其中疑似AIDS死亡者483例.快速进展者200例(7.8%),长期不进展者337例(13.1%).AIDS潜伏期为8.5～8.9年,发病率为11.7～12.0例/100人年;HIV生存时间8.8～10.7年,死亡率为6.9～8.3例/100人年;AIDS生存时间为1.2～2.0年,死亡率为34.9～51.5例/100人年.结论 通过对结局事件的时点调整,获得相对可靠的既往有偿献血员HIV感染者的AIDS潜伏期、AIDS生存时间和HIV生存时间,分别为8.8年、1.2年和9.8年. |
| English Abstract: |
| Objective To investigate the natural history of HIV infection caused by contaminated plasma donation among former commercial plasma donors in China. Methods Ambispective cohort study among HIV/AIDS cases and suspected AIDS deaths was conducted from January 1,1995 to March 31,2008 in 7 administrative villages in Shangcai county of Henan province.Information regarding diagnostic criteria, deaths and anti-retrovirus treatment was collected.Incubation and survival time were calculated using Kaplan-Meier and life-tables method. Sensitive analysis on the time of outcome was conducted. Results A total number of 2569 cases of HIV infection including 483 suspected AIDS deaths were involved in a cohort. 200 patients with rapid progress (7.8%) and 337 long-term but non-progressive patients (13.1%) were identified. Results from the sensitive analysis showed that the median incubation period from HIV infection to AIDS was between 8.5 and 8.9 years, with incidence as 11.7-12.0 cases/100 person-years and the median survival time for HIV progression to death was from 8.8 to 10.7 years, with the death rate as 6.9-8.3 cases/100 person-years. The median survival time for AIDS patient was from 1.2 to 2.0 years, with death rate as 34.9-51.5 cases/100 person-years. Conclusion According to sensitive analysis, the incubation period for HIV progression to AIDS, the median survival time for HIV progression to death and the median survival time for AIDS patient to death were 8.8 years, 1.2 years and 9.8 years,respectively. |
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