| 蒋立新,李希,李静,冯芳,CHENYi-ping,CHENZheng-ming,LandrayMartin,ArmitageJane.中国动脉粥样硬化性缺血性脑卒中患者他汀类药物应用现状调查[J].Chinese journal of Epidemiology,2010,31(8):925-928 |
| 中国动脉粥样硬化性缺血性脑卒中患者他汀类药物应用现状调查 |
| A cross-sectional study on the use of statin among patients with atherosclerotic ischemic stroke in China |
| Received:April 26, 2010 Revised:June 28, 2012 |
| DOI： |
| KeyWord: 脑卒中 他汀类药物 二级预防 现况调查 |
| English Key Word: Stroke Statin Secondary prevention Cross-sectional study |
| FundProject:国家重点基础研究发展计划(973计划)(2010CB529304);辽宁省教育厅优秀人才项目(2006R54) |
| Author Name | Affiliation | E-mail | | Jiang Lixin | China Oxford Centre for International Health Research Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
On Behalf of HPS2-THRIVE China Collaborative Group | lixin.jiang@fwoxford.org | | Li Xi | Department of Epidemiology & Biostatistics, School of Public Health,Peking University Health Science Center
On Behalf of HPS2-THRIVE China Collaborative Group | | | Li Jing | China Oxford Centre for International Health Research Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
On Behalf of HPS2-THRIVE China Collaborative Group | | | Feng Fang | China Oxford Centre for International Health Research Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
On Behalf of HPS2-THRIVE China Collaborative Group | | | CHEN Yi-ping | Clinical Trial Service Unit, Oxford University,UK
On Behalf of HPS2-THRIVE China Collaborative Group | | | CHEN Zheng-ming | Clinical Trial Service Unit, Oxford University,UK
On Behalf of HPS2-THRIVE China Collaborative Group | | | Landray Martin | Clinical Trial Service Unit, Oxford University,UK
On Behalf of HPS2-THRIVE China Collaborative Group | | | Armitage Jane | Clinical Trial Service Unit, Oxford University,UK
On Behalf of HPS2-THRIVE China Collaborative Group | |
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| Abstract: |
| 目的 了解中国动脉粥样硬化性缺血性脑卒中患者他汀类药物的使用现状,分析影响用药的相关因素.方法 借助一项在中国实施的国际多中心大规模临床试验,从国内10个城市39家三级医院筛查缺血性脑卒中患者5585例,利用电子问卷采集基线资料,对其中他汀类药物使用情况进行统计描述和分析.结果 所有筛查的缺血性脑卒中对象均为他汀类药物适应症者,其中病史在3个月至2年内的患者占60%.研究结果表明,高达80%的调查对象并未服用他汀类药物,即使服药,仍有四分之一的患者用药持续时间明显短于其罹患脑卒中的病史时间.合并冠心病的缺血性脑卒中患者,他汀类药物使用的比例高于单纯脑卒中者3倍.其中以使用辛伐他汀和阿托伐他汀最为广泛.结论 目前国内动脉粥样硬化性缺血性脑卒中患者,他汀类药物的使用严重不足,应予以高度重视. |
| English Abstract: |
| Objective To investigate the degree and determinants of the use on statin among patients with atherosclerotic ischernic stroke in China. Methods In the context of an international multi-center clinical trial being undertaken in China, 5585 patients with atherosclerotic ischemic stroke were screened in 39 prestigious hospitals in 10 cities. The characteristics collected through electronic questionnaire were described and analyzed. Results All the screened patients had indications for statins. Among those, 60% of the patients had a history from 3 months to 2 years of suffering from stroke. However, up to 80% of the patients were not using statins when screened. Even in those with statins, about 1/4 of the patients took statins for much shorter period than the history of stroke. The proportion using statins among IS patients with CHD was 4 times more than in those without CHD. Simvastatin and Atorvastatin were most commonly used. Conclusion Statins were greatly nnderused for secondary prevention among patients with atherosclerotic ischemic stroke in China. There was a large gap between evidence and practice. It remains a major challenge for healthcare professionals and policy makers to tackle this problem more positively. |
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