| 石晓鹏,杨建峰,钟华,邓峰美,王刚,王振焕,陈雄英,何芳.转化生长因子-β1基因多态性与新疆哈萨克族原发性高血压的关系[J].Chinese journal of Epidemiology,2010,31(9):1072-1074 |
| 转化生长因子-β1基因多态性与新疆哈萨克族原发性高血压的关系 |
| SNaPshot detect association of genetic polymorphisms in transforming growth factor Beta-1 with hypertension in the Kazakh ethnicities of Xinjiang |
| Received:November 27, 2009 |
| DOI： |
| KeyWord: 原发性高血压 转化生长因子-β1 基因多态性 |
| English Key Word: Essential hypertension Transforming growth factor Beta-1 Polymorphism |
| FundProject:国家自然科学基金(30760077) |
| Author Name | Affiliation | E-mail | | SHI Xiao-peng | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | YANG Jian-feng | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | ZHONG Hua | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | DENG Feng-mei | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | WANG Gang | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | WANG Zhen-huan | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | CHEN Xiong-ying | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | | | HE Fang | Department of Pathophysiology/ Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, Xinjiang 832002, China | fangf2002shz@126.com |
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| Abstract: |
| 原发性高血压(EH)是一类由多基因和环境因素共同影响导致的复杂遗传性疾病,是最常见的慢性心血管病之一,其病因和发病机制尚未完全阐明.新疆哈萨克族人群是EH易感人群,居全国各民族高血压患病率的前5位[1].哈萨克族人群居住在气候寒冷,交通不便,相对隔离的山区,无异族通婚史,有着鲜明的民族聚集和高发的特征.目前国内外有关单核苷酸多态性(SNP)与疾病的关联研究,在SNP位点的选择上除了注意功能区(启动子和外显子)外,由于不同连锁标记间连锁不平衡(LD)模式,为增加基因分型的有效性,还需进行标签SNP(tagSNP)与疾病的关联研究.由于转化生长因子-β1(TGF-β1)基因是血压和血管重构的重要调节因子,可能导致高血压的发病,而TGF-β1基因多态性在高血压中的作用尚无确切结果,因此本研究采用SNaPshot技术对TGF-β1基因的tagSNP多态位点开展研究,以期进一步阐明基因型与EH发生的关联 |
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