| 向阳,孙凤,詹思延.谷胱甘肽S一转移酶M1、T1基因多态性与抗结核药物所致肝损害易感性的Meta分析[J].Chinese journal of Epidemiology,2010,31(10):1997-1200 |
| 谷胱甘肽S一转移酶M1、T1基因多态性与抗结核药物所致肝损害易感性的Meta分析 |
| Meta-analysis on the relationship between polymorphisms of Giutathione S-transferase M1 and T1 genes and the susceptibility to antituberculosis drug-induced liver injury |
| Received:March 04, 2010 |
| DOI：10.3760/cma.j.issn.0254—6450.2010.10.029 |
| KeyWord: 抗结核药物所致肝损害 谷胱甘肽s一转移酶 基因多念性 Meta分析 |
| English Key Word: Antituberculosis drug-induced liver injury Glutathione S-transferase Genetic polymorphism Metaanalysis |
| FundProject:国家自然科学基金(30960328) |
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| Abstract: |
| 结核病目前仍然是严重危害人类健康的公共卫生问题。研究发现，WHO推荐的标准短程化疗方案主要使用的三种一线药物异烟肼、利福平、吡嗪酰胺，均能引起不同程度、不同频度的不良反应，其中最主要的不良反应是肝损害。 |
| English Abstract: |
| Objective Through introduction of principal theory and algorithm of propensity score to design SAS macro programs for binary data.Methods Propensity score method was used to compare the differences of character variables between two groups, and the association of DNR (Do Not Resuscitate) with the mortality of congestive heart failure was evaluated with different methods.Results Significant differences among the character variables between two groups were effectively balanced with stratification or matching method. The odds ratios of DNR with the in-hospital mortality rate of congestive heart failure were estimated identical with different algorithms and to find that the association of DNR to in-hospital mortality was highly significant. Conclusions Propensity score was a good algorithm that could be used to analyze any kind of observational data for matching the effects among the character variables. |
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