| 胡志坚,薛金发,张小阳,史习舜,周红.ERCC1基因多态性与肝癌易感性研究[J].Chinese journal of Epidemiology,2010,31(11):1288-1291 |
| ERCC1基因多态性与肝癌易感性研究 |
| Relationship between genetic polymorphism of ERCC1 and susceptibility to liver cancer |
| Received:April 28, 2010 |
| DOI： |
| KeyWord: 肝肿瘤 病例对照研究 基因多态性 |
| English Key Word: Liver cancer ERCCl Case-control study Gene polymorphism |
| FundProject:福建省G然科学基金(C0710019);福州市科技资助项S(2006S-G24) |
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| Abstract: |
| 目的 研究ERCCI基因多态性与福州地K人群肝癌易感性之间关系, 及其与环境因素交互作用对肝癌发牛的影响。方法 采用病例对照研究收集病例和对照暴露信息, 采用聚合_链反应限制性片段K度多态性(PCR-RFLP)技术对ERCCI-C8092A基因多态性进行检测;通过广义线性模拟ERCCI-C8092A基因多态性与肝癌主要环境危险因素交互作用的结构模型。结果 以ERCCI-C8092ACC作为参照, ERCCI-C8092ACA/AA基因型可以增加原发性肝癌的发病危险性(OR=3.789, 95%a:2.792?5.142);ERCCI-C8092A突变与饮沟塘水、乙型肝炎病毒感染的联合作用最适模均为超相加模墦, 与霉变食品联合作用为超相乘模型。结论 ERCCI-C8092A多态可能与肝癌遗传易感有关, 并与肝癌主要环境闵素间存在协同作用。 |
| English Abstract: |
| Objective To investigate the association between genetic polymorphisms of ERCCI-C8092A and susceptibility to liver cancer, as well as the gene-environmental interaction on the etiology of liver cancer in Fuzhou. Methods A case-control study was conducted to collect the information on environmental exposure while genetic polymorphism of ERCCl was analyzed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. General relative risk regression models were further applied to fit the interaction between genetic polymorphisms of ERCCI-C8092A and the environmental factors of liver cancer. Results ERCCI-C8092A variant genotypes were associated with significant increasing risk of liver cancer adjusted odds ratio(0R=3.789, 95%CI：2.792-5.142), compared to the wild-type homozygote. Data from the analysis of interaction showed that genetic polymorphism of ERCCI-C8092A appeared super?additive interaction with drinking pond-ditch or with hepatitis B, and super-multiplicative interaction with eating moldy food. Conclusion The point mutation in ERCC卜8Q92A was possibly susceptible to liver cancer, and related synergistically with other risk factors in hepatocelluar carcinogenesis in Fuzhou. |
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