| 崔运勇,王峰,刘小立,桂静,胡思玉,杨慧.深圳市结核分枝杆菌异烟肼耐药流行株的基因分析[J].Chinese journal of Epidemiology,2010,31(11):1317-1318 |
| 深圳市结核分枝杆菌异烟肼耐药流行株的基因分析 |
| Analysis of the epidemical INH-resistant Mycobacterium tuberculosis by DNA sequencing in Shenzhen |
| Received:April 13, 2010 |
| DOI： |
| KeyWord: 结核分枝杆菌 耐药 异烟肼 |
| English Key Word: Mycobacterium tuberculosis Dmg-resistance Isoniazid |
| FundProject:国家科技4大专项(2008ZX10003-004) |
| Author Name | Affiliation | E-mail | | CUI Yun- yong | Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China
School of Life Sciences, Xiamen University | | | WANG Feng | Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China | | | LIU Xiao-li | Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China | | | GUI Jing | Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China | | | HU Si-yu | School of Life Sciences, Xiamen University | | | YANG Hui | Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China | yh2009cn.yahoo.com.cn |
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| Abstract: |
| 异烟肼(INH)和利福平(RFP)是抗结核药中的一线药物,近年来出现了大蟹耐药结核分枝杆菌,在中国INH耐药率高达17．6％。INH耐药相关的最主要基因为katG,其次为inhA、ahpC和inhA94。为了解深圳地区INH耐药流行株的主要基因突变类型,本研究对深圳地区303株结核分枝杆菌的katG、inhA、oxyR-ahpC基因进行序列分析。 |
| English Abstract: |
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