| 巨韩芳,王撷秀,李桂莲,谢彤,赵德福,李尚伦,李敬新,赵慧,穆成.天津市北京基因型结核分枝杆菌流行特征及与耐药表型关系研究[J].Chinese journal of Epidemiology,2011,32(2):116-119 |
| 天津市北京基因型结核分枝杆菌流行特征及与耐药表型关系研究 |
| Characteristics of Mycobacterium tuberculosis genotype and the relationship between Beijing genotype and drug-resistant phenotypes in Tianjin |
| Received:September 10, 2010 |
| DOI： |
| KeyWord: 结核分枝杆菌 北京基冈型 耐药 |
| English Key Word: Mycobaeterium tuberculosis Beijhag genotypcs Drug resistance |
| FundProject:国家“十一五”艾滋病和病毒性肝炎等重大传染病防治项目(2008ZXl0003-009) |
| Author Name | Affiliation | E-mail | | JU hanfang | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | WANG xiexiu | Tianfin Center for Disease Control and Prevention | wjsaigo@126．Conl | | LI guilian | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | XIE tong | Tianfin Center for Disease Control and Prevention | | | CHAO defu | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | LI shanglun | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | LI jingxin | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | CHAO hui | Tianjin Center forTuberculosis Control, Tianjin 300041, China | | | MU cheng | Tianjin Center forTuberculosis Control, Tianjin 300041, China | |
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| Abstract: |
| 目的 了解北京基因型结核分枝杆菌在天津市人群中的分布、流行特征及其与耐药表型的关系。方法 收集2008年1月至2009年6月天津市结核病控制中心和10个区(县)结核病防治机构肺结核患者中初次分离培养的结核分枝杆菌656株及患者管理信息、临床信息和实验室信息。菌株对利福平、异烟肼、链霉素和乙胺丁醇的药物敏感性试验采用比例法。应用多重PCR法鉴定北京和非北京基因型菌株，并分析北京基因型菌株与耐药表型的关系。结果 本研究中菌株的总耐药率为26．98％，耐多药率为6．25％。北京基因型菌株600株(91．46％)，非北京基因型56株(8．53％)，其分布与天津市户籍(x2=4．26，P=0．039)有关，未见与耐药表型间有明显相关性。结论 北京基因型菌株是天津市的主要流行株，感染北京基因型结核分枝杆菌的天津市户籍患者的比例明最高于本地区流动人口患者，但尚未发现北京和非北京基因型菌株之间在耐药方面有明显的差异。 |
| English Abstract: |
| Objective To explore the distribution and characteristics on genotype of Mycobacterium tuberculosis and the relationship between Beijing genotype and drug．resistant phenotypes in Tianjin city．Methods 656 clinical strains were collected from Tianjin Center for Tuberculosis Control and ten other Tuberculosis Institute in Tianjin from January 2008 to June 2009． Information regarding administration．clinical as well as laboratory findings of patients were collected． Proportion method WaS adopted to detect the susceptibility on four anti．tuberculosis drugs．namely streptomycin(SM)。isoniazid(INH)，rifampicin(RFP)and ehambutol(EMB)．Both Beijing and non-Beijing genotypes were differentiated by multiplex PCR．The relationship between Beijinggenotype and drug-resistant phenotypes WaS analyzed．Results In this study，the overall resistance rate of MTB WaS 26．98％，with multidrug-resistant rate WaS 6．25％．Among 656 MTB strains。600 isolates(91．46％)belonged to Beijing genotype．There was significant difference between Beijing and non-Beijing genotype x2=4．26，P=O．039)among the Tianjin household registered population． Concerning the drug resistance，there was no significant difference between the two groups． Conclusion Bering genotype strains were the predominant one in Tianjin．The proportion of people infected with the Beijing genotype strains in Tianjin household registration of patients WaS significantly higher than the proportion of patients in the floating population in the same region． Results from the statistical analysis did not reveal any statistically significant association between Beijing genotype and drug resistance． |
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