亚裔女性乳腺癌危险因素的Meta分析

陶苹; 胡耀月; 黄源; 李佳圆

Abstract

陶苹,胡耀月,黄源,李佳圆.亚裔女性乳腺癌危险因素的Meta分析[J].Chinese journal of Epidemiology,2011,32(2):164-169

亚裔女性乳腺癌危险因素的Meta分析

Risk factors of breast cancer in Asian women：a Meta-analysis

Received:July 29, 2010

DOI：

KeyWord: 乳腺肿瘤危险因素 Meta分析乳腺癌风险预测模型

English Key Word: Breast neoplasm Risk factors Meta-analysis Breast cancer risk assessment model

FundProject:

Author Name	Affiliation	E-mail
TAO Ping	The Secon dPeople’s Hospital of Sichuan, Chengdu 610041, China
HU Yao-yue	Department of Epidemiology, Huaxi School of Public Health, Sichuan University
HUANG Yuan	Department of Epidemiology, Huaxi School of Public Health, Sichuan University
LI Jia-yuan	Department of Epidemiology, Huaxi School of Public Health, Sichuan University	lijiayuan73@163．Com

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Abstract:

目的综合评价亚裔女性乳腺癌的危险因素及关联强度,为建立风险预测模型提供依据.方法系统地收集1995-2010年亚裔女性乳腺癌危险因素的相关研究文献;按照NOS标准对纳入文献进行质量评价;采用RevMan 4.2软件进行数据分析,得到合并的OR值及其95%CI.结果纳入合格研究文献27篇,共计研究对象403 170例.文献质量评价A级文献20篇、B级文献7篇,纳入文献质量较高;有统计学意义的乳腺癌危险因素依次为流产次数≥3次、有乳腺癌家族史、初产年龄≥30岁、吸烟、未生育史、未哺乳史、初潮年龄≤12岁和饮酒,OR值分别为3.00(95%CI: 1.68～5.36)、2.39(95%CI:1.78～3.21)、1.54(95%CI: 1.30～1.82)、1.50(95%CI:1.03～2.20)、1.48(95%CI:1.20～1.83)、1.29(95%CI:1.12～1.47)、1.26(95%CI:1.07～1.49)和1.16(95%CI:1.01～1.32).结论流产次数≥3次、有乳腺癌家族史、初产年龄≥30岁、吸烟、未生育史、未哺乳史、初潮年龄≤12岁和饮酒是建立亚裔女性乳腺癌风险预测模型首要考虑的危险因素

English Abstract:

Objective To evaluate the risk factors of breast cancer in Asian women and to provide evidences for establishing a risk assessment model. Methods Published studies concerning risk factors of breast cancer in Asian women were searched systemically and assessed by NOS (Newcastle-Ottawa Scale) items between 1995 and 2010. RevMan 4.2 software was used for data analysis and for calculating OR and its 95%CI on every risk factor. Results 27 studies including 403170 women were selected for Meta-analysis. According to NOS items, 20 studies were classified as A degree and 7 studies were evaluated as B degree. The risk factors of breast cancer and its pooled odds ratio values with statistical significance were as follows: 3.00 (95%CI: 1.68-5.36) when number of abortions≥3; 2.39 (95%CI: 1.78-3.21 ) when with family history of breast cancer; 1.54(95%CI: 1.30-1.82) when age at first live birth ≥30 (year); smoking was 1.50(95%CI: 1.03-2.20); 1.48(95%CI:1.20-1.83) with no live births; 1.29 (95%CI: 1.12-1.47) with no breast feeding; 1.26 (1.07-1.49)with age at menarche ≤12 (year) and 1.16(95%CI: 1.01-1.32) with alcohol drinking. Conclusion Number of abortions≥3, family history of breast cancer, age at first live birth ≥30 (year),smoking, no live births, no breast feeding, age at menarche ≤ 12 (year), and alcohol drinking were among the priorities in the establishment of breast cancer risk assessment model for Asian women.

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