| 邵晓丹,张铁军,何纳.单纯疱疹病毒2型新发感染率及其危险因素的Meta分析[J].Chinese journal of Epidemiology,2011,32(2):170-176 |
| 单纯疱疹病毒2型新发感染率及其危险因素的Meta分析 |
| Meta．analysis on the ineidence and risk factors of herpes simplex virus type 2 infection |
| Received:September 03, 2010 |
| DOI： |
| KeyWord: 单纯疱疹病毒，2型 新发感染率 危险因素 Meta分析 |
| English Key Word: Herpes simplex virus type 2 Incidence Risk factors Meta-analysis |
| FundProject:国家“十一五”传染病科技重大专项(2008ZXl0001-003；2008ZXl0001-016) |
| Author Name | Affiliation | E-mail | | SHAO Xiao-dan | Department of Epidemiology, School of Public Health, Fudan University, the KeyLaboratory of Public Health Safety o fMinistry of Education, Shanghai 200032, China | | | ZHANG Tie-jun | Department of Epidemiology, School of Public Health, Fudan University, the KeyLaboratory of Public Health Safety o fMinistry of Education, Shanghai 200032, China | | | HE Na | Department of Epidemiology, School of Public Health, Fudan University, the KeyLaboratory of Public Health Safety o fMinistry of Education, Shanghai 200032, China | nhe@shmu．edu.cn |
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| Abstract: |
| 目的 描述全球单纯疱疹病毒2型(HSV-2)新发感染率水平,探讨其新发感染的危险因素.方法 运用Meta分析方法对全球范围内1990-2010年发表的HSV-2新发感染率相关研究结果进行汇总和定量综合分析;采用Stata软件进行异质性检验及合并新发感染率、发病风险比、计算发表偏倚和敏感性分析.结果 不同国家地区和不同人群间HSV-2新发感染率相差较大,自1.0/100人年至23.1/100人年之间不等.非洲、美国为HSV-2高发地区;女性和既往HIV感染是HSV-2新发感染的危险因素,但既往HSV-1感染对HSV-2的新发感染无影响.结论 不同国家地区和不同人群HSV-2新发感染率水平差异较大,需采取有针对性的防控策略.我国也应尽快在不同地区和人群中开展HSV-2新发感染率的相关研究. |
| English Abstract: |
| Objective To determine the global incidence and risk factors of herpes simplex virus type 2 (HSV-2). Methods Meta-analysis was performed to systematically and quantitatively review all the original research papers and reports that were published in 1990-2010 on the global incidence of HSV-2. Pooled incidence, pooled hazard ratios, publication bias, heterogeneity and sensitivity analysis for those studies were calculated or conducted using Stata 10.0. Results HSV-2incidence varied considerably across different countries, regions and/or populations, with a range from 1.0 to 23.1/100 person-years (PYs). Africa and United States were highly epidemic with HSV-2 while females and HIV-infected people were at higher risk of HSV-2 infection, whereas HSV-1 infection status was not significantly associated with acquisition of HSV-2 infection. Conclusion HSV-2incidence varied considerably among countries, regions and populations, which called for different and tailored control strategies. More research was also needed in China to examine the HSV-2 incidence and risk factors in different regions and populations. |
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