江苏省苏州市2009--2010年甲型H1N1流感住院病例抗病毒药物使用情况调查

查日胜; 张钧; 陈立凌; 朱保平; 张丽杰

Abstract

查日胜,张钧,陈立凌,朱保平,张丽杰.江苏省苏州市2009--2010年甲型H1N1流感住院病例抗病毒药物使用情况调查[J].Chinese journal of Epidemiology,2011,32(4):385-387

江苏省苏州市2009--2010年甲型H1N1流感住院病例抗病毒药物使用情况调查

The use of antiviral drugs in treating novel influenza A(HINl)inpatients in Suzhou city，Jiangsu province.China.2009-2010

Received:January 28, 2011

DOI：

KeyWord: 甲型H1NI流感抗病毒药物奥司他韦

English Key Word: Novelin fluenceA(HlNl) Antiviraldrug Oseltamivir

FundProject:

Author Name	Affiliation	E-mail
Zha Risheng	Suzhou Center for Disease Control and Prevention。Suzhou 215004. China
Zhang Jun	Suzhou Center for Disease Control and Prevention。Suzhou 215004. China
Chen Liling	Suzhou Center for Disease Control and Prevention。Suzhou 215004. China
Zhu Baoping	Chinese FkU Epidemiotogy Training Programt CFETP, Chinese Center for Disease Control and Prevention
Zhang Lijie	Chinese FkU Epidemiotogy Training Programt CFETP, Chinese Center for Disease Control and Prevention	zhang_li_jie@hotmail．com

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Abstract:

目的了解甲型H1NI流感大流行期间流感住院病例抗病毒药物使用情况及存在的问题。方法选择苏州市3家市级医院。查看2009年6月至2010年3月甲型HINI流感大流行期间住院治疗的甲型H1N1流感病例的病历资料，了解抗病毒药物的使用情况及有关信息。结果98％(222／226)的甲型HINl流感住院病例在住院期间使用过抗病毒药物，其中92％(205／222)使用过神经氨酸酶抑制剂——奥司他韦，但仅18％是在发病后2 d内开始用药。未发现医院对住院甲型HINl流感病例使用金刚烷胺、金刚乙胺等抗病毒药物。对医生进行访谈发现，就诊延迟、医生误诊、等待实验室检测与结果反馈等因素影响奥司他韦的及时使用。结论在甲型HINl流感大流行期间，苏州市3家市级医院绝大多数住院病例使用了奥司他韦，但药物使用及时性差。需要开发甲型HINI流感病毒的快速检测技术，提高医生的诊断水平，以缩短病例诊断时间，提高用药的时效性，改善这类抗病毒药物的使用效果。

English Abstract:

Objective To explore the use of antiviral drugs in treating the hospitalized patients ofnovel influence A(HlNl)in Suzhou city during the 2009-2010 influenza pandemic，SO as to make the proper lIse of antiviral drugs during influenza epidemics．Methods We selected 3 municipal hospitals and reviewed the medical records of hospimlizcd patients suffered from novel influenee A(HlNl)during June 2009 to March 2010．to gather antiviral USe and other related information．Results 98％(222／226)of the hospimlized patients received antiviral treatment．Among them，92％(205／222)were given the neuraminidase inhibitor oseitamivir．Howevel"。only 1 8％of the patients who received oscltamivir were given the treatment within 2 days after the onset of the illness．Amantadine and rimantadine were not used for any of the hospimlized patients．Through interview Oil the physicians，we identified that delay in seeing Cal'_e，misdiagnosis，delay in laboratory diagnosis were factors affecting the timely USe of oseltamivir．Conclusion The majority of the hospitalized patients suffered from novel influence A(H l N1)in the three municipal hospitals received oseltamivir treatment．However.in most occasions the drug Was not used timely．Techniques of rapid detection and diagnosis for novel influenza A(HlNl)virus should be developed．and the diagnostic capabilities of the physicians improved。to increase the effectiveness ofthese antiviral drugs．

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