广州地区2009年乙型流感病毒血凝素基因特征分析

董婉妮; 关文达; 廖伟娇; 罗翌; 王玉涛; 秦笙; 占扬清; 张雪; 黄群娣; 招穗珊; 周荣; 莫自耀; 杨子峰

Abstract

董婉妮,关文达,廖伟娇,罗翌,王玉涛,秦笙,占扬清,张雪,黄群娣,招穗珊,周荣,莫自耀,杨子峰.广州地区2009年乙型流感病毒血凝素基因特征分析[J].Chinese journal of Epidemiology,2011,32(5):524-526

广州地区2009年乙型流感病毒血凝素基因特征分析

Characteristic analyses on hemagglutinin gene of influenza B viruses isolated in Guangzhou, during 2009

Received:November 16, 2010

DOI：

KeyWord: 乙型流感病毒血凝素基因

English Key Word: Influenza B viruses Hemagglutinin Gene

FundProject:广东省高等学校科技创新重点联合攻关项目(gxzd0901);呼吸疾病国家重点实验室开放课题(A10103);广州市医药卫生科技项目(2008-YB-146);澳门科学技术发展基金(058/2009/A2);"十一五"国家科技重大专项(2009ZX10602-13)

Author Name	Affiliation	E-mail
DONG Wan-ni	First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
GUAN Wen-da	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
LIAO Wei-jiao	First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China
LUO Yi	Emergency Department of Guangdong Provincial Hospital of Traditional Chinese Medicine
WANG Yu-tao	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
QIN Sheng	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
ZHAN Yang-qing	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
ZHANG Xue	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
HUANG Qun-di	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
ZHAO Sui-shan	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
ZHOU Rong	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
MO Zi-yao	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College
YANG Zi-feng	State Key Laboratory of Respiratory Disease, First Affiliated Hospital of Gnangzhou Medical College	jeffyah@163.com

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Abstract:

根据抗原性和基因特异性的差异,乙型流感病毒可分为B/Victoria/2/87系(Victoria系)和B/Yamagata/16/88系(Yamagata系)^[1].血凝素(HA)基因与该病毒的进化趋势相关^[2],HA的抗原变异主要发生在HA1区域^[3],该区域4个主要的抗原表位[120-loop(HA1 116-137)、150-loop(HA1141-150)、160-loop(HA1 162～167)和190-helix(HA1194-202)]如发生变化,往往引起变异相关病毒株进化方向的改变^[4].为了解2009年乙型流感病毒进化情况,本研究分析了HA1基因特点.

English Abstract:

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