北京市2006--2008年急性弛缓陛麻痹与手足口病关联分析

罗明; 龚成; 张铁钢; 张朱佳子

Abstract

罗明,龚成,张铁钢,张朱佳子.北京市2006--2008年急性弛缓陛麻痹与手足口病关联分析[J].Chinese journal of Epidemiology,2011,32(7):681-684

北京市2006--2008年急性弛缓陛麻痹与手足口病关联分析

Study on the prevalence of acute flaccid paralysis and hand foot mouth disease in Beijing 2006-2008

Received:January 04, 2011

DOI：

KeyWord: 手足口病急性弛缓性麻痹肠道病毒7l型

English Key Word: Hand foot mouth disease Acute flaccid paralysis Enterovirus 71

FundProject:

Author Name	Affiliation	E-mail
LUO Ming	Beijing Center for Disease Control and Prevention, Beijing 100013, China
GONG Cheng	Beijing Center for Disease Control and Prevention, Beijing 100013, China	gongchen91109@lgmail．com
ZHANG Tie-gang	Beijing Center for Disease Control and Prevention, Beijing 100013, China
ZHANG Zhu-jia-zi	Beijing Center for Disease Control and Prevention, Beijing 100013, China

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Abstract:

目的探讨北京市手足口病流行对急件弛缓性麻痹(AFP)发病的影响及其流行病学联系。方法分析2006--2008年北京市AFP发病情况。对AFP病例利用RD、L20B细胞分离及鉴定病毒，并对非脊髓灰质炎肠道病毒(NPEV)阳性标本进行肠道病毒71型(EV71)和柯萨奇病毒A16型(CoxAl6)检测。通过国家法定传染病报告系统收集2008年北京市手足口病发病数据，并对北京市2008年AFP发病情况与手足口病流行特点进行比较和分析。结果2006--2008年北京市AFP报告病例数从108例增加到177例，NPEV分离率从II．1l％上升到20．34％，EV71和CoxAl6两种病毒总检出率从0．93％上升到10．17％。结论EV71和CoxAl6可能是AFP发病增加的重要原因。这部分病例并不表现出疹等手足I=I病的典型症状，而是以AFP为惟一表现，尤其是在手足口病流行期。这部分病例所占比例更高。

English Abstract:

Objective To study the prevalence of acute flaccid paralysis(AFP)and hand foot mouth disease(HFMD)in Beijing。from 2006—2008．Methods Data on AFP and HFMD was analyzed epidemiologically．during 2006—2008 in Beijing．All the specimens from AFP cases were isolated and identified bv RD and L20B cell and a11 of non-polio enterovirus(NPEV)cases were assayed bv HFMD real—time PCR kit．The relationship between AFP and HFMD Was analyzed．Results During 2006—2008．the number ofAFPCasC in Beijing increased from 108 to 177 while the NPEV isolation rate increased from 11．1l％to 20．34％and the positive rate ofenterovims 71(EV71) and／or coxsackie virus A16(COX A16)increased from 0．93％to 10．17％．Conclusion The prevalence of HFMD caused bv EV71 and／or Cox A16 might have contributed to the increase ofAFP cases in Beijing．

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