职业暴露和生活接触的低频电磁场与成年人急性髓系白血病——基于病例对照研究的Meta分析

王星; 王小钦; 顾静文

Abstract

王星,王小钦,顾静文.职业暴露和生活接触的低频电磁场与成年人急性髓系白血病——基于病例对照研究的Meta分析[J].Chinese journal of Epidemiology,2011,32(8):821-826

职业暴露和生活接触的低频电磁场与成年人急性髓系白血病——基于病例对照研究的Meta分析

Occupational and residential exposure to electric and magnetic field and its relationship on acute myeloid leukemia in adults — A Meta-analysis

Received:February 24, 2011

DOI：

KeyWord: 白血病急性髓系危险因素电磁场病例对照研究 Meta分析

English Key Word: Acute myeloid leukemia Risk factors Electromagnetic fields Case-control study Meta-analysis

FundProject:国家自然科学基金(30771853)

Author Name	Affiliation	E-mail
Wang Xing	Huashan Hospital,Fudan University,Shanghai 200040,China
Wang Xiao-qin	Huashan Hospital,Fudan University,Shanghai 200040,China	wangxiaoqin@shmu.edu.cn
Gu Jing-wen	Huashan Hospital,Fudan University,Shanghai 200040,China	jingwengu@yahoo.com

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Abstract:

目的<\b>研究职业或居住环境中暴露于电磁场与成年人罹患急性髓系白血病（AML）危险因素的关系。方法<\b>收集发表于1980－2010 年共9 篇相关病例对照研究，用RevMan 5.0 软件进行Meta 分析。结果<\b>电磁场暴露与AML的OR 值为1.24（95%CI：1.11～1.37）。以暴露强度＜0.1 μT 为参照，当暴露值分别为0.1～0.2 μT 和≥0.2 μT 时，分别为OR＝1.17（95%CI：0.98～1.39）和OR＝1.51（95%CI：1.15～1.98）。结论<\b>Meta 分析显示极低频电磁场可能是成年人AML的危险因素之一。进一步对暴露距离、职业暴露或居住环境暴露进行亚组分析，也均揭示电磁场可增加成年人AML的患病风险。

English Abstract:

Objective Studies had suggested that risk of leukemia might be associated with occupational or residential exposures to electromagnetic fields and varied at distance to and level of the exposure or type of occupations. Through pooled analyses，etiologic insight on the associations between exposure and disease might be explained.Methods We carried out a Meta-analysis based on primary data（1980-2010） from 9 studies related to the electric and magnetic fields exposure and acute myeloid leukemia in adults to assess whether the combined results，adjusted for potential confounding，would indicate an association between them.Results In this study the overall estimated OR value was 1.24（95%CI：1.11-1.37）. The odds ratios for exposure categories of 0.1-0.2 μT，≥ 0.2 μ T，compared with ＜0.1 μ T，were 1.17（95% CI：0.98-1.39）and 1.51（95% CI：1.15-1.98）， respectively.Conclusion Through employing the alternate cut points，stratification by level of exposure or distance and the relation on different ways of exposure，there appeared consistent evidence of increased risk between acute myeloid leukemia in adults and the extremely low frequencyelectromagnetic to field exposure.

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