叶酸预防神经管畸形服用方法<\b>研究进展

于海涛; 程宁; 白亚娜

Abstract

于海涛,程宁,白亚娜.叶酸预防神经管畸形服用方法<\b>研究进展[J].Chinese journal of Epidemiology,2011,32(8):834-836

叶酸预防神经管畸形服用方法<\b>研究进展

Progress on using folic acid to prevent neural tube defects

Received:February 25, 2011

DOI：

KeyWord: 叶酸神经管畸形

English Key Word: Folic acid Neural tube defects

FundProject:国家科技支撑计划（2006BAI05A01）

Author Name	Affiliation	E-mail
Yu Hai-tao	,Laboratory of Lanzhou University First Hospital,Lanzhou 730000,China
Cheng Ning	Reproductive Health and Research Center for Birth Defects,Lanzhou University	chengn@lzu.edu.cn
Bai Ya-na	Reproductive Health and Research Center for Birth Defects,Lanzhou UniversityCollege of Public Health,Institute of Epidemiology and Health Statistics,Lanzhou University

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Abstract:

神经管畸形（NTDs）是造成孕妇流产、围产儿和婴儿死亡及终身残疾的主要原因之一。NTDs存活者对家庭和社会造成了严重的经济和社会负担。目前叶酸预防NTDs研究取得了较好的成果，但对妇女增补叶酸的最佳时点尚有不同认识。妇女在正确时间内补充合理剂量的叶酸，对降低NTDs的发生和提高叶酸的利用率具有重要现实意义。现将近年来有关研究进展综述如下。

English Abstract:

compare the clinical manifestations of gastroenteritis caused by norovirus and rotavirus in infants and young children in Beijing.Methods Stool specimens were collected from infants and young children with acute diarrhea who visited the Affiliated Children's Hospital to Capital Institute of Pediatrics from January 2002 to December 2006.Registration form was designed for clinical data collection for each patient from whom specimen was collected.Poly-acrylamide gel electrophoresis (PAGE) and enzyme immunoassay (EIA) were used to detect rotavirus and Human norovirus,respectively.Results Among 779 stool specimens tested for rotavirus,263 were positive (33.8 %),and norovirus positive specimens were 79 out of 318 (24.8%) specimens tested.Most of the clinical manifestations of gastroenteritis caused by these two viruses were quite similar with no significant difference,except for fever.The seasonal distribution of these two viruses were different with the peak of rotavirus infection was in cold weather between October and January,as indicated by the peak of the positive rates of the virus detection.The infection of norovirus seemed no obvious peak in the year.Conclusion Rotavirus is the most important pathogen for acute diarrhea among infants and young children while.Norovirus is also an important pathogen for acute gastroenteritis in infants and young children.No significant difference was found out for clinical manifestations for the gastroenteritis caused by these two viruses.

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