| 严海燕,钟日辉,李竞,罗晓红,陈瑞.多肿瘤标志物蛋白芯片在老年人健康筛查中的应用[J].Chinese journal of Epidemiology,2011,32(9):924-926 |
| 多肿瘤标志物蛋白芯片在老年人健康筛查中的应用 |
| Application of multiple tumor markers' s protein chip in the green program of the elderly |
| Received:March 31, 2011 |
| DOI： |
| KeyWord: 蛋白芯片 多肿瘤标志物 老年人 健康体检 |
| English Key Word: Protein chip Multiple tumor markers Old people Healthy screening |
| FundProject: |
| Author Name | Affiliation | E-mail | | AN Hai-yan | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China | | | ZHONG Ri-hui | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China | | | LI Jing | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China | | | LUO Xiao-hong | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China | | | CHEN Rui | Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China | gzchherui@163.com |
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| Abstract: |
| 目的 评估多肿瘤标志物蛋白芯片(C12芯片)在老年人健康筛查中的应用。方法C12芯片包含甲胎蛋白(AFP)、神经特异性烯醇化酶(NSE)、前列腺特异抗原(PSA)、游离前列腺特异抗原(f-PSA)、癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原153(CA153)、糖类抗原199(CA199)、糖类抗原242(CA242)、β-人绒毛膜促性腺激素(β-HCG)、人类生长激素(HGH)、铁蛋白(ferritin)，利用C12芯片对399例体检老年人及对照组1791例成人体检者血清进行检测，以超出正常范围为阳性结果。结果老年人组与对照组均检测到AFP、PSA、f-PSA、CEA、CA125、CA153及CA199有阳性结果，其阳性率差异有统计学意义(P＜0.05)；老年人组与对照组中AFP、PSA、f-PSA、CEA、CA125、CA199、CA242及ferritin的正常检测值差异有统计学意义(P＜0.05)。结论C12芯片中AFP、PSA、f-PSA、CEA、CA125、CA153及CA199肿瘤标志物可用于老年人的健康筛查，有助于发现早期肿瘤。 |
| English Abstract: |
| Objective To evaluate the application of the multiple tumor markers' s protein chip (C12 chip) in the screen program of the elderly. Methods The C12 chip included alpha-fetoprotein (AFP), neuron-specific enolase (NSE), prostate special antigen (PSA), frce-PSA(f-PSA), carcinoembryonic antigen ( CEA ), carbohydrate antigen 125 (CA 125 ), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), carbohydrate antigen 242 (CA242), human chorionic gonagotropin-bcta ( β-HCG), human growth hormone (HGH) and fcrritin. The sera of the 399 healthy elderly under the screening program and 1791 adults were detected by the C12 chip.Definition of positive was set as: one or more tumor markers higher than or equal to the reference value.Results The positive rates of AFP, PSA, f-PSA, CEA, CA125, CA153 and CA199 between the elderly group and the adult group were significantly different (P＜0.05). The normal test value of AFP, PSA, f-PSA, CEA, CA 125, CA 199, CA242 and ferritin between the elderly group and the adult group were significantly different (P＜ 0.05 ).Conclusion AFP, PSA, f-PSA, CEA, CA 125, CA 153and CA199 of the C12 chip were useful in the screening program of the elderly to discover the sign of tumor at an early stage. |
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