| 李晓蕾,于锋,张永,仇锦春,刘思婷,廖清船.5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性 关系的Meta分析[J].Chinese journal of Epidemiology,2011,32(10):1030-1036 |
| 5,10-亚甲基四氢叶酸还原酶C677T基因多态性与急性淋巴细胞白血病易感性 关系的Meta分析 |
| Study on the association between 5, 10-methylenetrahydrofolate reductase C677T polymorphism and acute lymphoblastic leukemia risk: a Meta-analysis |
| Received:May 05, 2011 |
| DOI：1 0.3760/cma.j.issn.0254-6450.2011. 10.018 |
| KeyWord: 急性淋巴细胞白血病 5，10-亚甲基四氢叶酸还原酶 基因多态性 Meta分析 |
| English Key Word: Acute lymphoblastic leukemia 5, 10-methylenetrahydrofolate reductase Gene polymorphism Meta-analysis |
| FundProject: |
| Author Name | Affiliation | E-mail | | LI Xiao-lei1 | Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China | | | YU Feng | Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China | | | ZHANG Yong | Nanjing Children's Hospital, Nanjing Medical University | | | QIU Jin-chun | Nanjing Children's Hospital, Nanjing Medical University | | | LIU Si-ting | Nanjing Children's Hospital, Nanjing Medical University | | | LIAO Qing-chuan | Nanjing Children's Hospital, Nanjing Medical University | lqc730220@126.com |
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| Abstract: |
| 目的 运用Meta分析的方法综合评价5，10-亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性与急性淋巴细胞白血病(ALL)的相关性。方法 制定原始文献的纳入和排除标准及检索策略。检索中外文数据库，收集有关MTHFR基因C677T多态性与ALL相关性的研究报告，采用TT/CC+CT以及TT/CC基因型比较模型进行定量综合分析，然后按年龄（儿童或成年人） 分亚组进行分析。结果 综合分析显示，MTHFR基因677位点TT/CC+ CT、TT/CC模型计算OR值(95%CI)分别为0.87（0.69～1.09）、0.82(0.63～ 1.06)；在儿童组TT/CC+ CT、TT/CC模型计算OR 值(95%CI)分别为0.92(0.79～1.08)、0.88（0.75～1.05），在成年人组TT/CC+CT、TT/CC模型计算 OR值(95%CI)分别为0.45(0.26 ～0.77)、0.41(0.22～0.72)。结论 MTHFR基因C677T突变与儿 童ALL无关联，但可能减弱成年人ALL发生的危险。 |
| English Abstract: |
| To evaluate the association between polymorphism of 5, 10- methylenetrahydrofolate reductase C677T and risk of acute lymphoblastic leukemia (ALL). Methods Electronic search strategy was carried out among the databases from home and abroad to collect qualified research papers, according to the inclusion and exclusion criteria. Data on case-control studies on association between MTHFR C677T polymorphism and susceptibility to ALL were colleted and analyzed by models of TT vs. CC + CT or TT vs. CC through Meta-analysis. Stratified analysis was carried out according to different age groups (children or adult). Results In systematical analysis, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.87 (0.69-1.09 ) and 0.82 ( 0.63-1.06 ) respectively; in children' s group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.92 ( 0.79-1.08), 0.88 ( 0.75-1.05 ) while in adult group, the pooled odds ratios of MTHFR C677T genetype TT vs. CC + CT or TT vs. CC were 0.45 (0.26-0.77), and 0.41 (0.22-0.72) respectively. Conclusion The MTHFR gene 677T variant might not be associated with the risk of children's ALL but might be associated with a reduced risk on adult's ALL. |
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