中国人群瘦素受体Gln223Arg、Pr01019Pro基因多态性与肥胖关联性的Meta分析

阳赣萍; 彭司华; 左双燕; 王一任; 彭小宁; 曾小敏

Abstract

阳赣萍,彭司华,左双燕,王一任,彭小宁,曾小敏.中国人群瘦素受体Gln223Arg、Pr01019Pro基因多态性与肥胖关联性的Meta分析[J].Chinese journal of Epidemiology,2011,32(10):1037-1042

中国人群瘦素受体Gln223Arg、Pr01019Pro基因多态性与肥胖关联性的Meta分析

Meta-analysis on the relationship between leptin receptor Gln223Arg and Prol019Pro gene polymorphism and obesity in the Chinese population

Received:March 09, 2011

DOI：10.3760/cma.j.issn.0254-6450.2011.10.019

KeyWord: 瘦素受体 LEPR Gln223Arg LEPR Prol019Pro 基因多态性肥胖 Meta分析

English Key Word: Leptin receptor LEPR Gln223Arg LEPR Prol019Pro Gene polymorphism Obesity Meta-analysis

FundProject:

Author Name	Affiliation	E-mail
YANG Gan-ping	Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China
PENG Si-hua	Department of Pathology, Zhejiang University School of Medicine
ZUO Shuang-yan	Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China
WANG Yi-ren	Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China
PENG Xiao-ning	Department of Pathology, Zhejiang University School of Medicine
ZENG Xiao-min	Department of Epidemiology and Health Statistics, School of Public Health, Central South University, Changsha 410078, China	zxiaonin@xysm.net

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Abstract:

目的探讨瘦素受体(LEPR)Gln223Arg、Prol019Pro基因多态性与肥胖的关联性。方法计算机检索万方、CNKI、维普、CBM、PubMed、EMBASE数据库，收集1979-2010年公开发表的关于中国人群LEPR Gln223Arg、LEPR Pro1 019Pro基因多态性与肥胖的病例对照研究的文献，选择OR值及其95%CI作为Meta分析指标。利用Stata 10.0软件对各研究结果进行异质性检验和效应值合并计算。结果根据统一的纳入和剔除标准，纳入15篇文献，其中LEPR Gln223Arg基因多态性相关文献9篇，共有肥胖者1096例，对照组949人；LEPR Prol019Pro基因多态性相关文献8篇，共有肥胖者961例，对照组818人。LEPR Gln223Arg基因多态性与肥胖关联性的研究中，LEPR-668位点基因G/A的OR=0.66（95%CI:0.49～0.89)，将有A→3基因突变的AG基因型和GG基因型合并后与AA基因型比较，肥胖易感性降(OR=0.50,95%CI: 0.32～ 0.77)有统计学意义；在LEPR Prol019Pro基因多态性与肥胖关联性的研究中，LEPR-3057位点基因A/G的OR= 1,61 (95%CI: 1.15～2.26)，有G→A基因突变的基因型AG和基因型AA合并后与GG基因型比较，肥胖易感性升高（OR= 1.50，95%CI: 1.08～2.08)，有统计学意义。结论中国汉族为主的人群LEPR Gln223Arg和LEPR Prol019Pro基因多态性与肥胖的发生均有关联。

English Abstract:

To evaluate the associations between polymorphisms of LEPR Gln223Arg, LEPR Pro 1019Pro and the risk on obesity. Methods A computerized search on literature was carried out in Wanfang, CNKI, VIP databases and CBM, PubMed, EMBASE databases to collect articles published between 1979 and 2010 concerning the associations between polymorphisms of LEPR Gln223Arg and/or LEPR Pro 1019Pro and risk of obesity in the Chinese population. Odds ratios (ORs) were used to assess the strength of the association, and 95% confidence intervals (CIs) to present the precision of the estimates. Meta-analysis was performed using the STATA statistical software. Results Fifteen literature were collected for Meta-analysis by the uniform inclusion and exclusion criteria. There were 1096 obese patients and 949 controls for polymorphisms of LEPR Gln223Arg in 9 papers, together with 961 obese patients and 818 controls for polymorphisms of LEPR Prol019Pro in 8 papers. Overall, there were significant associations between decreased risk of obesity and LEPR Gln223Arg polymorphisms (-668 A→G) (G versus A, OR=0.66,95%CI: 0.49-0.89; AG and GG versus AA, OR=0.50,95%CI: 0.32-0.77; respectively). There were significant associations between increased risk of obesity and LEPR Prol019Pro polymorphisms (-3057 G→A) (A versus G, OR= 1.61,95%CI: 1.15-2.26; AG and AA versus GG, OR= 1.50, 95%CI: 1.08-2.08; respectively). Conclusion Variant alleles at both LEPR-668 and LEPR-3057 were associated with obesity in the Chinese Han-dominated population.

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