| 吴凯,陈晓平,高音,张昕,李龙心,万里艳.血清尿酸对2型糖尿病预测价值的分析[J].Chinese journal of Epidemiology,2011,32(11):1153-1157 |
| 血清尿酸对2型糖尿病预测价值的分析 |
| Predictive value of serum uric acid on type 2 diabetes mellitus |
| Received:May 25, 2011 Revised:June 28, 2012 |
| DOI： |
| KeyWord: 尿酸 高尿酸血症 糖尿病 2型 空腹血糖 |
| English Key Word: Uric acid Hyperuricemia Type 2 diabetes mellitus Fasting blood glucose |
| FundProject:“十一五”国家科技支撑计划(2006BAI01A01) |
| Author Name | Affiliation | E-mail | | WU Kai | Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China
Department of Cardiology,903 Hospital | wukuaidewenzang@163.com | | CHEN Xiao-ping | Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China | | | GAO Yin | Department of Cardiology,903 Hospital | | | ZHANG Xin | Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China | | | LI Long-xin | Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China | | | WAN Li-yan | Department of Cardiology,West China Hospital,Sichuan University,Chengdu 610041,China | |
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| Abstract: |
| 目的 分析成都地区1992年中年居民血清尿酸水平对2007年该人群2型糖尿病患病的预测价值。方法 1992年进行代谢综合征研究时共纳入1061人，其中年龄45 ～ 60岁且血糖正常者共71 1人，并依据血清尿酸水平分为尿酸正常组及增高组，采用x2检验和logistic回归分析1992年高尿酸血症与2007年该人群（711人）2型糖尿病患病率的相对危险度（RR）。结果 (1)1992年血尿酸增高人群在2007年时空腹血糖(FBG)皆高于尿酸正常人群，t检验示组间FBG的差异有统计学意义。2007年糖尿病患病率亦呈类似FBG的特点，为尿酸增高组高于尿酸正常组，经X2检验，组间糖尿病患病率差异有统计学意义。(2)根据该队列人群1992年血尿酸增高与否，计算2007年2型糖尿病患病，RR=3.749，P=0.000,95%CI:2.387 ～ 5.890。(3)使用logistic回归模型分析1992年基线血尿酸对2007年2型糖尿病患病的影响，在调整了其他危险因素后，高尿酸血症RR=1.426，P=0.003，95%CI:1.173～1.705。结论 尿酸异常与血糖代谢异常关系密切，高尿酸血症可预测2型糖尿病的发生。 |
| English Abstract: |
| Objective To evaluate the predictive value of uric acid (UA) on type 2 diabetes mellitus (DM).Methods 711 subjects aged 45-60 years old with normal fasting blood glucose (FBG) were studied in 1992.The subjects were divided into 2 groups according to their 1992 UA data in the normal UA group and in the hyperuricemia (HUA) group.We analyzed the prevalence of DM-2 in 2007 according to data on UA in 1992. Relative risk (RR) of the cohort was calculated under x2 test and logistic regression analysis.Results FBG and the prevalence rate of DM in 2007 in the HUA group were statistically higher than those in the normal group.The relative risk (RR) of HUA to DM was 3.749 (P=0.000),with 95% Confidence interval (CI) as 2.387-5.890.Data from the logistic regression analysis,after adjusting for other risk factors,the RR of UA to DM was 1.426 (P＝0.003),with 95% CI as 1.173-1.705.Conclusion The abnormal UA was closely related to glucose metabolism disorder while hyperuricemia appeared to be associated with increased risk of type 2 DM. |
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