上海市浦东新区居民高尿酸血症与慢性肾病相关性研究

周弋; 齐慧; 赵根明; 杨黎明; 孙乔

Abstract

周弋,齐慧,赵根明,杨黎明,孙乔.上海市浦东新区居民高尿酸血症与慢性肾病相关性研究[J].Chinese journal of Epidemiology,2012,33(4):351-355

上海市浦东新区居民高尿酸血症与慢性肾病相关性研究

Relationship between hvperuricemia and chronic kidney disease in Pudong New Area of Shanghai

Received:October 25, 2011

DOI：

KeyWord: 尿酸高尿酸血症慢性肾病横断面研究

English Key Word: Uric acid Hyperuricaemia Chronic kidney disease Cross-sectional study

FundProject:本课题受上海市浦东新区卫生局卫生科技发展专项基金(PW2009A-24)及上海市浦东新区卫生系统重点学科建设(PWZxk2010-09)资助

Author Name	Affiliation	E-mail
ZHOU Yi	School of Public Health, Fudan University, Shanghai 200032, China Shanghai Pudong New Area Center for Disease Control and Prevention
QI Hui	Shanghai Pudong New Area Center for Disease Control and Prevention	qihuil971@hotmail.com
ZHAO Gen-ming	School of Public Health, Fudan University, Shanghai 200032, China
YANG Li-ming	Shanghai Pudong New Area Center for Disease Control and Prevention
SUN Qiao	Shanghai Pudong New Area Center for Disease Control and Prevention

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Abstract:

目的了解上海市浦东新区社区居民高尿酸血症(HUA)及血清尿酸(SUA)水平与慢性肾病(CKD)的关系.方法 2008年4-7月从浦东新区随机抽取20 ～ 80岁社区居民3326人进行问卷调查,收集一般情况和生活方式等信息,并采集空腹血和晨尿,检测SUA、肌酐(SCr)及尿微量白蛋白等指标,计算尿白蛋白和肌酐比值(ACR),并依SCr水平计算肾小球滤过率(GFR).结果上海市浦东新区成年居民CKD粗患病率为16.0％(标化患病率为13.2％).CKD及非CKD者的GFR均值分别为(89.19±27.25)和(105.88±98.37)ml ·min-1·(1.73 m2)-1.依SUA水平将调查对象按四分位分为4组(第一组:＜4.2 mg/dl;第二组:≥4.2 mg/dl且＜5.0 mg/dl;第三组:≥5.0 mg/dl且＜6.0 mg/dl;第四组:≥6.0 mg/dl),CKD患病率分别为13.9％、15.0％、15.8％和19.4％(P＜0.05),且无论男女CKD患病率随着SUA水平升高有增加趋势.以SUA第一组为参照进行logistic回归分析,第二、三、四组的调整OR值分别为1.19(95％CI:0.90～ 1.58)、1.27(95％CI:1.02 ～ 1.70)、1.28(95％CI:1.10 ～ 1.68).结论上海市浦东新区成年居民中,HUA可能是CKD的独立危险因素.

English Abstract:

Objective To investigate the relationships between hyperuricaenia,serum uric acid (SUA) level and the chronic kidney disease (CKD) in adult residents of Pudong New Area,Shanghai.Methods 3326 residents aged 20-80 years were randomly selected from Pudong New Area,Shanghai through multistage sampling and interviewed between April and July of 2008.Fasting blood sample and morning ovid urine sample were collected for each participant for testing of SUA,serum creatinine,urinary albumin and creatinine.Both urine albumin to creatinine ratio (ACR)and glomerular filtration rate (GFR) were calculated to estimate the renal function.Results The overall prevalence of CKD was 16.0％ (age standardized 13.2％ ).The mean values of estimated GFR in participants with CKD and without CKD were (89.19 ± 27.25) and ( 105.88 ± 98.37) ml· min-1 ·(1.73 m2) -1,respectively.The prevalence rates of CKD in serum uric acid quartiles:first quartile,less than 4.2 mg/dl; second quartile,4.2-5.0 mg/dl; third quartile,5.0-6.0 mg/dl; and fourth quartile,6.0 mg/dl or more were 13.9％,15.0％,15.8％and 19.4％ (P＜0.05) respectively,increasing along with the increase of SUA among both sexes.Compared to the serum uric acid first quartile,the multivariate-adjusted odds for CKD of the second,third and fourth quartiles were 1.19 [95％ confidence interval (CI):0.90-1.58],1.27 (95％ CI:1.02-1.70),1.28 (95％ CI:1.10-1.68),respectively. Conclusion Hyperuricaemia was independently associated with the increased prevalence of CKD among population living in the Pudong New Area,Shanghai.

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