现场干预试验中人群尿碘频数的分析

宋银吟; 牟李红; 李革; 王豫林; 肖邦忠; 李心术; 雷音

Abstract

宋银吟,牟李红,李革,王豫林,肖邦忠,李心术,雷音.现场干预试验中人群尿碘频数的分析[J].Chinese journal of Epidemiology,2012,33(5):492-495

现场干预试验中人群尿碘频数的分析

Analysis on the frequency of urinary iodine in a population—based intervention study

Received:November 12, 2011

DOI：

KeyWord: 尿碘水平尿碘频数社区十预试验队列人群

English Key Word: rinary iodine level Urinary iodinefrequency Community intervention Cohort

FundProject:重庆市“十一五”科技发展规划重大专项(CSTC，2007AB5034)

Author Name	Affiliation	E-mail
Song Yinyin	Department of Epidemiology．School of Public Health and Management．Chongqing Medical University．Chongqing 400016. China
Mou Lihong	Department of Epidemiology．School of Public Health and Management．Chongqing Medical University．Chongqing 400016. China	mulihong@yahoo．com
Li Ge	Department of Epidemiology．School of Public Health and Management．Chongqing Medical University．Chongqing 400016. China
Wang Yulin	Chongqing Center for Disease Control and Prevemion
Xiao Bangzhong	Chongqing Center for Disease Control and Prevemion
Li Xinshu	Chongqing Center for Disease Control and Prevemion
Lei Yin	Salt Administration of Chongqing

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Abstract:

目的分析不同剂量食盐加碘干预后队列人群的尿碘频数，探索较为适宜且安全的碘盐浓度。方法2007--2010年采用多级整群随机抽样方法抽取观察对象，以抽样A、B县的各3个乡镇为单位进行不同食盐加碘浓度[(15--+5)、(25-+5)、(35-+5)mg／kg]的社区干预，随访观察分析干预后队列人群的尿碘频数变化。结果下调浓度后，2县4个试验乡镇人群尿碘中位数随着干预时间逐步降低。A县(15±5)mg／kg和(25±5)mg／kg组儿童尿碘频数主要集中在100～200μg/l和200～300μg/l。B县儿童尿碘频数>300μg/l总体有所下降，100μg/l／L和200～μg/l比例升高，但趋势较为缓慢。4个试验组尿碘频数100—300μg/l的比例较大且保持平稳，始终处于一个较理想的状态；对照组仍以>250。g／L为主。结论建议在重庆市逐步实施分类补碘，在经济较发达地区可将食盐碘浓度从现行的(35±15)mg／kg下调至(25+5)mg／kg，并继续随访其变化。

English Abstract:

Objective Through a two-year follow up program this study was to analyze the urinary iodine frequency of a cohort in the intervention trial,concerning different doses of saltiodization,SO as to explore the selection of appropriate concentration of salt iodization.Methods A multistage cluster sampling method was used to select three townships in two countries for communi Wintervention with different doses[(15±5)mg／kg,(25±5)mg／kg,(355)mg／kg] ofsaltiodization.Results After intervention,the median of urinary iodine was reduced among the population.The urinary iodine frequencies of (15±5)mg and(25±5)mg／kg among groups of children were mainly concentrated in 100—200μg/L and 200-300μg/L paragraphs in A county.While the300μg/L paragraph had an overall decline in B county,the100μg/Land 200μg/L paragraph ratio increased but the trend seemed to be slow.The 100--300μg/L paragraph of the four treatment groups took alarger proportion and kepts mooth in a more ideal state.However,the control group still maintained at above 250μg/L level.Conclusion The iodine supplementation should be gradually implemented in Chongqing.The doses of salt iodization should be reduced from the current(35±15)mg／kg to(25±5)mg/kgin the economically developed areas.At the same time,we need to continuously follow the changes of the condition.

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