| 方喜业,周冬生,崔玉军,李艳君,刘起勇,许磊,杨瑞馥.中国鼠疫自然疫源地分型研究Ⅲ．鼠疫耶尔森菌DFR／MLVA主要基因组型生物学特征[J].Chinese journal of Epidemiology,2012,33(5):536-539 |
| 中国鼠疫自然疫源地分型研究Ⅲ．鼠疫耶尔森菌DFR／MLVA主要基因组型生物学特征 |
| Eco-geographicl and scapes of natural plague foci in China III．Biological charactedsfics of major DFR／MLVA-based genotypes of Yersinia pestis,China |
| Received:February 18, 2012 |
| DOI： |
| KeyWord: 鼠疫耶尔森菌 差异区段／多位点串联重复序列基因组型 |
| English Key Word: Yersinia pestis Different region(DFR)／Multi-locus VNTR analysis(MLVA)-based gcnotypes |
| FundProject:国家科技重大专项(2008ZXl0004-010) |
| Author Name | Affiliation | E-mail | | Fang Xiye | Institute of Laboratory Animal Sciences of Chinese Academy of Medical Sciences, Compained Medical Research Center of Peking Union Medical College, Beijing 100021, China | xiyefang@hotmail．Com | | Zhou Dongsheng | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | | Cui Yujun | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | | Li Yanjun | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | | Liu Qiyong | State Key Laborawry for Infectious Disease Prevemion and Control, NationalInstitute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention | | | Xu Lei | Instaute of Zoology, Chinese Academy of Sciences | | | Yang Ruifu | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | yangrf@nic．bmi．ac．cn |
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| Abstract: |
| 鼠疫菌基因组型与鼠疫生态地理景观型及其主要宿主、媒介密切相关，自然组合形成鼠疫生物群落，互相依赖，互相制约，相互适应，同步进化，维持鼠疫自然疫源性和生物群落的延续。鼠疫菌差异区段／多位点串联重复序列(DF形ML讼)基因组型反映了鼠疫自然疫源地生物学特征。其型别对认识鼠疫菌自然疫源地生物学具有重要意义。通过对鼠疫菌基因组型的鉴定，可实现对鼠疫菌的追踪溯源，追溯出所代表的鼠疫主要宿主、主要媒介及其生态地理景观型的生物学特征。因此。鉴定鼠疫菌基因组型、主要基因组型对中国鼠疫预防控制、应急反恐、生物安全、监测预报及软件技术平台体系建设具有实践和理论指导意义。 |
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