方喜业,周冬生,崔玉军,李艳君,刘起勇,许磊,杨瑞馥.中国鼠疫自然疫源地分型研究Ⅲ.鼠疫耶尔森菌DFR/MLVA主要基因组型生物学特征[J].Chinese journal of Epidemiology,2012,33(5):536-539 |
中国鼠疫自然疫源地分型研究Ⅲ.鼠疫耶尔森菌DFR/MLVA主要基因组型生物学特征 |
Eco-geographicl and scapes of natural plague foci in China III.Biological charactedsfics of major DFR/MLVA-based genotypes of Yersinia pestis,China |
Received:February 18, 2012 |
DOI: |
KeyWord: 鼠疫耶尔森菌 差异区段/多位点串联重复序列基因组型 |
English Key Word: Yersinia pestis Different region(DFR)/Multi-locus VNTR analysis(MLVA)-based gcnotypes |
FundProject:国家科技重大专项(2008ZXl0004-010) |
Author Name | Affiliation | E-mail | Fang Xiye | Institute of Laboratory Animal Sciences of Chinese Academy of Medical Sciences, Compained Medical Research Center of Peking Union Medical College, Beijing 100021, China | xiyefang@hotmail.Com | Zhou Dongsheng | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | Cui Yujun | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | Li Yanjun | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | | Liu Qiyong | State Key Laborawry for Infectious Disease Prevemion and Control, NationalInstitute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention | | Xu Lei | Instaute of Zoology, Chinese Academy of Sciences | | Yang Ruifu | Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences | yangrf@nic.bmi.ac.cn |
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Abstract: |
鼠疫菌基因组型与鼠疫生态地理景观型及其主要宿主、媒介密切相关,自然组合形成鼠疫生物群落,互相依赖,互相制约,相互适应,同步进化,维持鼠疫自然疫源性和生物群落的延续。鼠疫菌差异区段/多位点串联重复序列(DF形ML讼)基因组型反映了鼠疫自然疫源地生物学特征。其型别对认识鼠疫菌自然疫源地生物学具有重要意义。通过对鼠疫菌基因组型的鉴定,可实现对鼠疫菌的追踪溯源,追溯出所代表的鼠疫主要宿主、主要媒介及其生态地理景观型的生物学特征。因此。鉴定鼠疫菌基因组型、主要基因组型对中国鼠疫预防控制、应急反恐、生物安全、监测预报及软件技术平台体系建设具有实践和理论指导意义。 |
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