血清一氧化氮水平与微量蛋白尿关系1∶2病例对照研究

刘海英; 彭浩; 汤玲燕; 张诗卉; 高昕; 晁湘琴; 张永红

Abstract

刘海英,彭浩,汤玲燕,张诗卉,高昕,晁湘琴,张永红.血清一氧化氮水平与微量蛋白尿关系1∶2病例对照研究[J].Chinese journal of Epidemiology,2012,33(7):746-749

血清一氧化氮水平与微量蛋白尿关系1∶2病例对照研究

Association between serum nitric oxide level and microalbuminuria:a 1 ∶ 2 matched case-control study

Received:December 12, 2011

DOI：

KeyWord: 一氧化氮微量蛋白尿

English Key Word: Nitric oxide Microalbuminuria

FundProject:本研究为苏州市科技项目(SS0910)资助

Author Name	Affiliation	E-mail
LIU Hai-ying	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China Department of Neurology, the First Peoples' Hospital of Horqin District, Inner Mongolia
PENG Hao	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China
TANG Ling-yan	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China
ZHANG Shi-hui	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China
GAO Xin	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China
CHAO Xiang-qin	Jinchang District Center for Disease Control and Prevention, Suzhou
ZHANG Yong-hong	Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou 215123, China	yhzhang@suda.edu.cn

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Abstract:

目的探讨血清一氧化氮水平与微量蛋白尿的关联性.方法以苏州市金阊区的高血压现场调查为基础,采用1∶2配对研究方法,选择208例微量蛋白尿患者及与之在性别、年龄、血糖和腰围相匹配的居住同一小区、同等经济收入水平的非微量蛋白尿人群,测量血清一氧化氮水平,采用多因素条件logistic回归对血清一氧化氮水平与微量蛋白尿的关联性进行分析.结果微量蛋白尿组的血清一氧化氮水平略低于非微量蛋白尿组(中位数,四分位间距:27.75,14.48～ 42.15μmol/L vs.28.25,17.40～ 43.45μmol/L),但两组间差异无统计学意义(P=0.316).多因素条件logistic回归分析显示,调整血压、血脂、尿酸、吸烟、饮酒后,血清一氧化氮水平与微量蛋白尿不存在显著关联性.进一步按是否患高血压分层,多因素条件logistic回归分析显示,与血清一氧化氮水平最高分位者相比,在多因素调整后,无论是在高血压还是非高血压的对子中,血清一氧化氮水平处于第1、2、3分位者患微量蛋白尿的危险性差异均无统计学意义.在有高血压的对子中,血清一氧化氮最低水平组患有微量蛋白尿的危险性是最高水平组的1.85倍(OR=1.85,95％CI:0.96～ 3.57);而在非高血压的对子中,血清一氧化氮最低水平组患有微量蛋白尿的危险性较最高水平组仅增加了40％(OR=1.40,95％CI:0.58 ～ 3.40).结论在一般人群中,血清一氧化氮水平与微量蛋白尿无显著相关性.

English Abstract:

Objective To investigate the association betweenserum nitric oxide and microalbuminuria.Methods Based on a community survey in Jinchang district Suzhou city,a 1 ∶ 2 matched case-control study was performed.A total of 208 cases with microalbuminuria were recruited.The controls were selected from the same community,with the same level of income.After matched with age,gender,waist circumference and fast plasma glucose,a total of 416 controls were selected.Values of serum nitric oxide were tested for all eligible participants.The association between serum nitric oxide level and microalbuminuria were analyzed by using the multivariate conditional logistic regression models.Results The mean level of serum nitric oxide was slightly lower for individuals with microalbuminuria (median,interquartile range:27.75,14.48-42.15 μmol/L) than those without (28.25,17.40-43.45 μ mol/L ).However,the difference was not statistically significant (P=0.316).Results from the multivariable conditional logistic regression model showed that serum nitric oxide level was not associated with microalbuminuria,after adjustment for all the confounders.Compared with the highest level of serum nitric oxide,the odds ratios of microalbuminuria for individuals in the 1 st,2nd and 3rd quartiles were not significantly different,after adjustment for confounders.In pairs with hypertension,the odds of microalbuminuria were 85％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.85,95％ CI:0.96-3.57).Additionally,in pairs without hypertension,the odds of microalbuminuria was just 40％ higher for individuals with the lowest level of serum nitric oxide than those with the highest level (OR=1.40,95％CI:0.58-3.40).Conclusion There was no significant correlation between serum nitric oxide and microalbuminuria in the general population in our study.

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